1ruo: Difference between revisions

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-[[Image:1ruo.gif|left|200px]]
- {{Structure
+==CATABOLITE GENE ACTIVATOR PROTEIN (CAP) MUTANT/DNA COMPLEX + ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE==
-|PDB= 1ruo |SIZE=350|CAPTION= <scene name='initialview01'>1ruo</scene>, resolution 2.700&Aring;
+<StructureSection load='1ruo' size='340' side='right'caption='[[1ruo]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND= <scene name='pdbligand=CMP:ADENOSINE-3&#39;,5&#39;-CYCLIC-MONOPHOSPHATE'>CMP</scene>
+<table><tr><td colspan='2'>[[1ruo]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RUO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RUO FirstGlance]. <br>
-|ACTIVITY=
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
-|GENE=
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CMP:ADENOSINE-3,5-CYCLIC-MONOPHOSPHATE'>CMP</scene></td></tr>
-}}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ruo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ruo OCA], [https://pdbe.org/1ruo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ruo RCSB], [https://www.ebi.ac.uk/pdbsum/1ruo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ruo ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CRP_ECOLI CRP_ECOLI] This protein complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons. The protein induces a severe bend in the DNA. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP.<ref>PMID:2982847</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ru/1ruo_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ruo ConSurf].
+<div style="clear:both"></div>
-'''CATABOLITE GENE ACTIVATOR PROTEIN (CAP) MUTANT/DNA COMPLEX + ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE'''
+==See Also==
+*[[Catabolite gene activator protein 3D structures|Catabolite gene activator protein 3D structures]]
+== References ==
-==About this Structure==
+<references/>
-RUO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RUO OCA].
+__TOC__
+</StructureSection>
-==Reference==
-Aromatic hydrogen bond in sequence-specific protein DNA recognition., Parkinson G, Gunasekera A, Vojtechovsky J, Zhang X, Kunkel TA, Berman H, Ebright RH, Nat Struct Biol. 1996 Oct;3(10):837-41. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8836098 8836098]
 [[Category: Escherichia coli]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Berman, H M.]]
+[[Category: Berman HM]]
-[[Category: Ebright, R H.]]
+[[Category: Ebright RH]]
-[[Category: Parkinson, G N.]]
+[[Category: Parkinson GN]]
-[[Category: CMP]]
-[[Category: activator]]
-[[Category: camp-binding]]
-[[Category: complex (gene-regulatory protein/dna)]]
-[[Category: dna-binding]]
-[[Category: gene-regulatory protein/dna complex]]
-[[Category: transcription regulation]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 13:31:33 2008''