1reg: Difference between revisions

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<StructureSection load='1reg' size='340' side='right'caption='[[1reg]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='1reg' size='340' side='right'caption='[[1reg]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1reg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1REG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1REG FirstGlance]. <br>
<table><tr><td colspan='2'>[[1reg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1REG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1REG FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1reg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1reg OCA], [http://pdbe.org/1reg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1reg RCSB], [http://www.ebi.ac.uk/pdbsum/1reg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1reg ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1reg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1reg OCA], [https://pdbe.org/1reg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1reg RCSB], [https://www.ebi.ac.uk/pdbsum/1reg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1reg ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/REGA_BPT4 REGA_BPT4]] Controls the translation of a number of proteins (such as regA itself, rIIB and at least 35 others) by binding to their mRNA.  
[https://www.uniprot.org/uniprot/REGA_BPT4 REGA_BPT4] Controls the translation of a number of proteins (such as regA itself, rIIB and at least 35 others) by binding to their mRNA.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1reg ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1reg ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The translational regulator protein regA is encoded by the T4 bacteriophage and binds to a region of messenger RNA (mRNA) that includes the initiator codon. RegA is unusual in that it represses the translation of about 35 early T4 mRNAs but does not affect nearly 200 other mRNAs. The crystal structure of regA was determined at 1.9 A resolution; the protein was shown to have an alpha-helical core and two regions with antiparallel beta sheets. One of these beta sheets has four antiparallel strands and has some sequence homology to RNP-1 and RNP-2, which are believed to be RNA-binding motifs and are found in a number of known RNA-binding proteins. Structurally guided mutants may help to uncover the basis for this variety of RNA interaction.
Crystal structure of the T4 regA translational regulator protein at 1.9 A resolution.,Kang C, Chan R, Berger I, Lockshin C, Green L, Gold L, Rich A Science. 1995 May 26;268(5214):1170-3. PMID:7761833<ref>PMID:7761833</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1reg" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Enterobacteria phage t4]]
[[Category: Escherichia virus T4]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Kang, C]]
[[Category: Kang C]]
[[Category: Rich, A]]
[[Category: Rich A]]
[[Category: Translational regulator protein]]

Latest revision as of 11:22, 14 February 2024

CRYSTAL STRUCTURE OF THE T4 REGA TRANSLATIONAL REGULATOR PROTEIN AT 1.9 ANGSTROMS RESOLUTIONCRYSTAL STRUCTURE OF THE T4 REGA TRANSLATIONAL REGULATOR PROTEIN AT 1.9 ANGSTROMS RESOLUTION

Structural highlights

1reg is a 2 chain structure with sequence from Escherichia virus T4. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.9Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

REGA_BPT4 Controls the translation of a number of proteins (such as regA itself, rIIB and at least 35 others) by binding to their mRNA.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

1reg, resolution 1.90Å

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