1qtf: Difference between revisions

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[[Image:1qtf.png|left|200px]]


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==CRYSTAL STRUCTURE OF EXFOLIATIVE TOXIN B==
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<StructureSection load='1qtf' size='340' side='right'caption='[[1qtf]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1qtf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QTF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QTF FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qtf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qtf OCA], [https://pdbe.org/1qtf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qtf RCSB], [https://www.ebi.ac.uk/pdbsum/1qtf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qtf ProSAT]</span></td></tr>
{{STRUCTURE_1qtf|  PDB=1qtf  |  SCENE=  }}
</table>
 
== Function ==
===CRYSTAL STRUCTURE OF EXFOLIATIVE TOXIN B===
[https://www.uniprot.org/uniprot/ETB_STAAU ETB_STAAU] Has serine protease-like properties and binds to the skin protein profilaggrin. Cleaves substrates after acidic residues. Exfoliative toxins cause impetigous diseases commonly referred as staphylococcal scalded skin syndrome (SSSS).<ref>PMID:2117445</ref> <ref>PMID:2384148</ref>
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
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==About this Structure==
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qtf ConSurf].
1QTF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QTF OCA].  
<div style="clear:both"></div>
 
== References ==
==Reference==
<references/>
The crystal structure of exfoliative toxin B: a superantigen with enzymatic activity., Vath GM, Earhart CA, Monie DD, Iandolo JJ, Schlievert PM, Ohlendorf DH, Biochemistry. 1999 Aug 10;38(32):10239-46. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10441117 10441117]
__TOC__
[[Category: Single protein]]
</StructureSection>
[[Category: Large Structures]]
[[Category: Staphylococcus aureus]]
[[Category: Staphylococcus aureus]]
[[Category: Earhart, C A.]]
[[Category: Earhart CA]]
[[Category: Monie, D D.]]
[[Category: Monie DD]]
[[Category: Ohlendorf, D H.]]
[[Category: Ohlendorf DH]]
[[Category: Schlievert, P M.]]
[[Category: Schlievert PM]]
[[Category: Vath, G M.]]
[[Category: Vath GM]]
[[Category: Serine protease]]
[[Category: Superantigen]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:58:54 2008''

Latest revision as of 11:17, 14 February 2024

CRYSTAL STRUCTURE OF EXFOLIATIVE TOXIN BCRYSTAL STRUCTURE OF EXFOLIATIVE TOXIN B

Structural highlights

1qtf is a 1 chain structure with sequence from Staphylococcus aureus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.4Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ETB_STAAU Has serine protease-like properties and binds to the skin protein profilaggrin. Cleaves substrates after acidic residues. Exfoliative toxins cause impetigous diseases commonly referred as staphylococcal scalded skin syndrome (SSSS).[1] [2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Bailey CJ, Smith TP. The reactive serine residue of epidermolytic toxin A. Biochem J. 1990 Jul 15;269(2):535-7. PMID:2117445
  2. ↑ Dancer SJ, Garratt R, Saldanha J, Jhoti H, Evans R. The epidermolytic toxins are serine proteases. FEBS Lett. 1990 Jul 30;268(1):129-32. PMID:2384148

1qtf, resolution 2.40Å

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