1qqm: Difference between revisions

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[[Image:1qqm.png|left|200px]]


{{STRUCTURE_1qqm|  PDB=1qqm  |  SCENE=  }}
==D199S MUTANT OF BOVINE 70 KILODALTON HEAT SHOCK PROTEIN==
 
<StructureSection load='1qqm' size='340' side='right'caption='[[1qqm]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
===D199S MUTANT OF BOVINE 70 KILODALTON HEAT SHOCK PROTEIN===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1qqm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QQM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QQM FirstGlance]. <br>
{{ABSTRACT_PUBMED_10451379}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qqm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qqm OCA], [https://pdbe.org/1qqm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qqm RCSB], [https://www.ebi.ac.uk/pdbsum/1qqm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qqm ProSAT]</span></td></tr>
[[1qqm]] is a 1 chain structure of [[Heat Shock Proteins]] with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QQM OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/HSP7C_BOVIN HSP7C_BOVIN] Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qq/1qqm_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qqm ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Heat Shock Proteins|Heat Shock Proteins]]
*[[Heat Shock Protein structures|Heat Shock Protein structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:010451379</ref><references group="xtra"/>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Johnson, E R.]]
[[Category: Large Structures]]
[[Category: Mckay, D B.]]
[[Category: Johnson ER]]
[[Category: Atpase]]
[[Category: Mckay DB]]
[[Category: Hydrolase]]
[[Category: Molecular chaperone]]

Latest revision as of 11:16, 14 February 2024

D199S MUTANT OF BOVINE 70 KILODALTON HEAT SHOCK PROTEIND199S MUTANT OF BOVINE 70 KILODALTON HEAT SHOCK PROTEIN

Structural highlights

1qqm is a 1 chain structure with sequence from Bos taurus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.9Å
Ligands:, , , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

HSP7C_BOVIN Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1qqm, resolution 1.90Å

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