1qil: Difference between revisions

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[[Image:1qil.gif|left|200px]]


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==INACTIVE MUTANT TOXIC SHOCK SYNDROME TOXIN-1 AT 2.5 A==
The line below this paragraph, containing "STRUCTURE_1qil", creates the "Structure Box" on the page.
<StructureSection load='1qil' size='340' side='right'caption='[[1qil]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1qil]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QIL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QIL FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qil FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qil OCA], [https://pdbe.org/1qil PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qil RCSB], [https://www.ebi.ac.uk/pdbsum/1qil PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qil ProSAT]</span></td></tr>
{{STRUCTURE_1qil| PDB=1qil |  SCENE= }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/TSST_STAAU TSST_STAAU] Responsible for the symptoms of toxic shock syndrome.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qi/1qil_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qil ConSurf].
<div style="clear:both"></div>


'''INACTIVE MUTANT TOXIC SHOCK SYNDROME TOXIN-1 AT 2.5 A'''
==See Also==
 
*[[Acetylcholinesterase 3D structures|Acetylcholinesterase 3D structures]]
 
__TOC__
==Overview==
</StructureSection>
Toxic shock syndrome toxin-1 (TSST-1) is one of a family of staphylococcal exotoxins recognized as microbial superantigens. The toxin plays a dominant role in the genesis of toxic shock in humans through a massive activation of the immune system. This potentially lethal illness occurs as a result of the interaction of TSST-1 with a significant proportion of the T-cell repertoire. TSST-1, like other superantigens, can bind directly to class II major histocompatibility (MHC class II) molecules prior to its interaction with entire families of V beta chains of the T-cell receptor (TCR). The three-dimensional structure of a mutant (His-135-Ala) TSST-1 was compared with the structure of the native (wild-type) TSST-1 at 2.5 A resolution. The replacement of His 135 of TSST-1 with an Ala residue results in the loss of T-cell mitogenicity and toxicity in experimental animals. This residue, postulated to be directly involved in the toxin-TCR interactions, is located on the major helix alpha 2, which forms the backbone of the molecule and is exposed to the solvent. In the molecular structure of the mutant toxin, the helix alpha 2 remains unaltered, but the His to Ala modification causes perturbations on the neighboring helix alpha 1 by disrupting helix-helix interactions. Thus, the effects on TCR binding of the His 135 residue could actually be mediated, wholly or in part, by the alpha 1 helix.
[[Category: Large Structures]]
 
==About this Structure==
1QIL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QIL OCA].
 
==Reference==
Crystal structure of a biologically inactive mutant of toxic shock syndrome toxin-1 at 2.5 A resolution., Papageorgiou AC, Quinn CP, Beer D, Brehm RD, Tranter HS, Bonventre PF, Acharya KR, Protein Sci. 1996 Aug;5(8):1737-41. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8844860 8844860]
[[Category: Single protein]]
[[Category: Staphylococcus aureus]]
[[Category: Staphylococcus aureus]]
[[Category: Acharya, K R.]]
[[Category: Acharya KR]]
[[Category: Papageorgiou, A C.]]
[[Category: Papageorgiou AC]]
[[Category: Staphylococcal enterotoxin]]
[[Category: Superantigen]]
[[Category: Toxin]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 06:19:08 2008''

Latest revision as of 11:15, 14 February 2024

INACTIVE MUTANT TOXIC SHOCK SYNDROME TOXIN-1 AT 2.5 AINACTIVE MUTANT TOXIC SHOCK SYNDROME TOXIN-1 AT 2.5 A

Structural highlights

1qil is a 3 chain structure with sequence from Staphylococcus aureus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.5Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TSST_STAAU Responsible for the symptoms of toxic shock syndrome.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1qil, resolution 2.50Å

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