1qa6: Difference between revisions

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-[[Image:1qa6.gif|left|200px]]<br /><applet load="1qa6" size="350" color="white" frame="true" align="right" spinBox="true"
-caption="1qa6, resolution 2.800&Aring;" />
-'''CRYSTAL STRUCTURE OF A CONSERVED RIBOSOMAL PROTEIN-RNA COMPLEX'''<br />
-==Overview==
+==CRYSTAL STRUCTURE OF A CONSERVED RIBOSOMAL PROTEIN-RNA COMPLEX==
-The structure of a highly conserved complex between a 58-nucleotide domain of large subunit ribosomal RNA and the RNA-binding domain of ribosomal protein L11 has been solved at 2.8 angstrom resolution. It reveals a precisely folded RNA structure that is stabilized by extensive tertiary contacts and contains an unusually large core of stacked bases. A bulge loop base from one hairpin of the RNA is intercalated into the distorted major groove of another helix; the protein locks this tertiary interaction into place by binding to the intercalated base from the minor groove side. This direct interaction with a key ribosomal RNA tertiary interaction suggests that part of the role of L11 is to stabilize an unusual RNA fold within the ribosome.
+<StructureSection load='1qa6' size='340' side='right'caption='[[1qa6]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1qa6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QA6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QA6 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=OS:OSMIUM+ION'>OS</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qa6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qa6 OCA], [https://pdbe.org/1qa6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qa6 RCSB], [https://www.ebi.ac.uk/pdbsum/1qa6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qa6 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/RL11_GEOSE RL11_GEOSE] Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qa/1qa6_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qa6 ConSurf].
+<div style="clear:both"></div>
-==About this Structure==
+==See Also==
-QA6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus] with <scene name='pdbligand=MG:'>MG</scene> and <scene name='pdbligand=OS:'>OS</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QA6 OCA].
+*[[Ribosomal protein L11 3D structures|Ribosomal protein L11 3D structures]]
+__TOC__
-==Reference==
+</StructureSection>
-Crystal structure of a conserved ribosomal protein-RNA complex., Conn GL, Draper DE, Lattman EE, Gittis AG, Science. 1999 May 14;284(5417):1171-4. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10325228 10325228]
+[[Category: Escherichia coli]]
 [[Category: Geobacillus stearothermophilus]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Conn, G L.]]
+[[Category: Conn GL]]
-[[Category: Draper, D E.]]
+[[Category: Draper DE]]
-[[Category: Gittis, A G.]]
+[[Category: Gittis AG]]
-[[Category: Lattman, E E.]]
+[[Category: Lattman EE]]
-[[Category: MG]]
-[[Category: OS]]
-[[Category: antibiotic binding]]
-[[Category: e rna-protein interaction]]
-[[Category: minor groove binding]]
-[[Category: ribosomal rna]]
-[[Category: tertiary structur]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:37:29 2008''