1q7s: Difference between revisions

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[[Image:1q7s.png|left|200px]]


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==Crystal structure of bit1==
The line below this paragraph, containing "STRUCTURE_1q7s", creates the "Structure Box" on the page.
<StructureSection load='1q7s' size='340' side='right'caption='[[1q7s]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1q7s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q7S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q7S FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q7s OCA], [https://pdbe.org/1q7s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q7s RCSB], [https://www.ebi.ac.uk/pdbsum/1q7s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q7s ProSAT]</span></td></tr>
{{STRUCTURE_1q7s|  PDB=1q7s  |  SCENE=  }}
</table>
 
== Function ==
===Crystal structure of bit1===
[https://www.uniprot.org/uniprot/PTH2_HUMAN PTH2_HUMAN] The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis (By similarity).<ref>PMID:15006356</ref>   Promotes caspase-independent apoptosis by regulating the function of two transcriptional regulators, AES and TLE1.<ref>PMID:15006356</ref>
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
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==About this Structure==
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1q7s ConSurf].
1Q7S is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q7S OCA].  
<div style="clear:both"></div>
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:14660562</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Jan, Y.]]
[[Category: Large Structures]]
[[Category: Pascual, J.]]
[[Category: De Pereda JM]]
[[Category: Pereda, J M.De.]]
[[Category: Jan Y]]
[[Category: Ruoslahti, E.]]
[[Category: Pascual J]]
[[Category: Schimmel, P.]]
[[Category: Ruoslahti E]]
[[Category: Waas, W F.]]
[[Category: Schimmel P]]
[[Category: Apoptosis]]
[[Category: Waas WF]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 21:31:14 2009''

Latest revision as of 11:13, 14 February 2024

Crystal structure of bit1Crystal structure of bit1

Structural highlights

1q7s is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PTH2_HUMAN The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis (By similarity).[1] Promotes caspase-independent apoptosis by regulating the function of two transcriptional regulators, AES and TLE1.[2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Jan Y, Matter M, Pai JT, Chen YL, Pilch J, Komatsu M, Ong E, Fukuda M, Ruoslahti E. A mitochondrial protein, Bit1, mediates apoptosis regulated by integrins and Groucho/TLE corepressors. Cell. 2004 Mar 5;116(5):751-62. PMID:15006356
  2. ↑ Jan Y, Matter M, Pai JT, Chen YL, Pilch J, Komatsu M, Ong E, Fukuda M, Ruoslahti E. A mitochondrial protein, Bit1, mediates apoptosis regulated by integrins and Groucho/TLE corepressors. Cell. 2004 Mar 5;116(5):751-62. PMID:15006356

1q7s, resolution 2.00Å

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