1q3h: Difference between revisions

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[[Image:1q3h.png|left|200px]]


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==mouse CFTR NBD1 with AMP.PNP==
The line below this paragraph, containing "STRUCTURE_1q3h", creates the "Structure Box" on the page.
<StructureSection load='1q3h' size='340' side='right'caption='[[1q3h]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1q3h]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q3H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q3H FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
{{STRUCTURE_1q3h|  PDB=1q3h  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q3h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q3h OCA], [https://pdbe.org/1q3h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q3h RCSB], [https://www.ebi.ac.uk/pdbsum/1q3h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q3h ProSAT]</span></td></tr>
 
</table>
===mouse CFTR NBD1 with AMP.PNP===
== Function ==
 
[https://www.uniprot.org/uniprot/CFTR_MOUSE CFTR_MOUSE] Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1 (By similarity).
 
== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
The line below this paragraph, {{ABSTRACT_PUBMED_14685259}}, adds the Publication Abstract to the page
Check<jmol>
(as it appears on PubMed at http://www.pubmed.gov), where 14685259 is the PubMed ID number.
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q3/1q3h_consurf.spt"</scriptWhenChecked>
{{ABSTRACT_PUBMED_14685259}}
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 
    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
[[1q3h]] is a 4 chain structure of [[ABC transporter]] with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q3H OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1q3h ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[ABC transporter]]
*[[ABC transporter 3D structures|ABC transporter 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:14685259</ref><references group="xtra"/>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Buchanan, S G.]]
[[Category: Buchanan SG]]
[[Category: Burley, S K.]]
[[Category: Burley SK]]
[[Category: Conners, K.]]
[[Category: Conners K]]
[[Category: Dickey, M.]]
[[Category: Dickey M]]
[[Category: Dorwart, M.]]
[[Category: Dorwart M]]
[[Category: Fowler, R.]]
[[Category: Fowler R]]
[[Category: Gao, X.]]
[[Category: Gao X]]
[[Category: Guggino, W B.]]
[[Category: Guggino WB]]
[[Category: Hendrickson, W A.]]
[[Category: Hendrickson WA]]
[[Category: Lewis, H A.]]
[[Category: Lewis HA]]
[[Category: Abc transporter nucleotide binding domain]]
[[Category: Membrane protein]]

Latest revision as of 11:12, 14 February 2024

mouse CFTR NBD1 with AMP.PNPmouse CFTR NBD1 with AMP.PNP

Structural highlights

1q3h is a 4 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.5Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CFTR_MOUSE Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1 (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1q3h, resolution 2.50Å

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OCA
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