1pta: Difference between revisions

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-[[Image:1pta.png|left|200px]]
-{{STRUCTURE_1pta|  PDB=1pta  |  SCENE=  }}
+==THREE-DIMENSIONAL STRUCTURE OF PHOSPHOTRIESTERASE: AN ENZYME CAPABLE OF DETOXIFYING ORGANOPHOSPHATE NERVE AGENTS==
+<StructureSection load='1pta' size='340' side='right'caption='[[1pta]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-===THREE-DIMENSIONAL STRUCTURE OF PHOSPHOTRIESTERASE: AN ENZYME CAPABLE OF DETOXIFYING ORGANOPHOSPHATE NERVE AGENTS===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1pta]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Brevundimonas_diminuta Brevundimonas diminuta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PTA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PTA FirstGlance]. <br>
-{{ABSTRACT_PUBMED_7999757}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pta FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pta OCA], [https://pdbe.org/1pta PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pta RCSB], [https://www.ebi.ac.uk/pdbsum/1pta PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pta ProSAT]</span></td></tr>
-==About this Structure==
+</table>
-[[1pta]] is a 1 chain structure of [[Phosphotriesterase]] with sequence from [http://en.wikipedia.org/wiki/Brevundimonas_diminuta Brevundimonas diminuta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PTA OCA].
+== Function ==
+[https://www.uniprot.org/uniprot/OPD_BREDI OPD_BREDI] Has an unusual substrate specificity for synthetic organophosphate triesters and phosphorofluoridates. All of the phosphate triesters found to be substrates are synthetic compounds. The identity of any naturally occurring substrate for the enzyme is unknown. Has no detectable activity with phosphate monoesters or diesters and no activity as an esterase or protease. It catalyzes the hydrolysis of the insecticide paraoxon at a rate approaching the diffusion limit and thus appears to be optimally evolved for utilizing this synthetic substrate.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pt/1pta_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pta ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Phosphotriesterase|Phosphotriesterase]]
+*[[Phosphotriesterase 3D structures|Phosphotriesterase 3D structures]]
+__TOC__
-==Reference==
+</StructureSection>
-<ref group="xtra">PMID:007999757</ref><references group="xtra"/>
 [[Category: Brevundimonas diminuta]]
-[[Category: Benning, M.]]
+[[Category: Large Structures]]
-[[Category: Holden, H M.]]
+[[Category: Benning M]]
+[[Category: Holden HM]]