1pl5: Difference between revisions

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[[Image:1pl5.png|left|200px]]


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==Crystal Structure Analysis of the Sir4p C-terminal Coiled Coil==
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<StructureSection load='1pl5' size='340' side='right'caption='[[1pl5]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1pl5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PL5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PL5 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pl5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pl5 OCA], [https://pdbe.org/1pl5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pl5 RCSB], [https://www.ebi.ac.uk/pdbsum/1pl5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pl5 ProSAT]</span></td></tr>
{{STRUCTURE_1pl5|  PDB=1pl5  |  SCENE=  }}
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== Function ==
===Crystal Structure Analysis of the Sir4p C-terminal Coiled Coil===
[https://www.uniprot.org/uniprot/SIR4_YEAST SIR4_YEAST] The proteins SIR1 through SIR4 are required for transcriptional repression of the silent mating type loci, HML and HMR. The proteins SIR2 through SIR4 repress mulitple loci by modulating chromatin structure. Involves the compaction of chromatin fiber into a more condensed form.<ref>PMID:18039933</ref>
 
== References ==
 
<references/>
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{{ABSTRACT_PUBMED_14636601}}
 
==About this Structure==
1PL5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PL5 OCA].  
 
==Reference==
The Sir4 C-terminal coiled coil is required for telomeric and mating type silencing in Saccharomyces cerevisiae., Murphy GA, Spedale EJ, Powell ST, Pillus L, Schultz SC, Chen L, J Mol Biol. 2003 Dec 5;334(4):769-80. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14636601 14636601]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Single protein]]
[[Category: Chen L]]
[[Category: Chen, L.]]
[[Category: Murphy GA]]
[[Category: Murphy, G A.]]
[[Category: Pillus L]]
[[Category: Pillus, L.]]
[[Category: Powell ST]]
[[Category: Powell, S T.]]
[[Category: Schultz SC]]
[[Category: Schultz, S C.]]
[[Category: Spedale EJ]]
[[Category: Spedale, E J.]]
[[Category: Parallel coiled coil homodimer]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:49:34 2008''

Latest revision as of 11:08, 14 February 2024

Crystal Structure Analysis of the Sir4p C-terminal Coiled CoilCrystal Structure Analysis of the Sir4p C-terminal Coiled Coil

Structural highlights

1pl5 is a 2 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.5Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SIR4_YEAST The proteins SIR1 through SIR4 are required for transcriptional repression of the silent mating type loci, HML and HMR. The proteins SIR2 through SIR4 repress mulitple loci by modulating chromatin structure. Involves the compaction of chromatin fiber into a more condensed form.[1]

References

  1. ↑ Bupp JM, Martin AE, Stensrud ES, Jaspersen SL. Telomere anchoring at the nuclear periphery requires the budding yeast Sad1-UNC-84 domain protein Mps3. J Cell Biol. 2007 Dec 3;179(5):845-54. Epub 2007 Nov 26. PMID:18039933 doi:http://dx.doi.org/10.1083/jcb.200706040

1pl5, resolution 2.50Å

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