1pho: Difference between revisions

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[[Image:1pho.gif|left|200px]]


{{Structure
==CRYSTAL STRUCTURES EXPLAIN FUNCTIONAL PROPERTIES OF TWO E. COLI PORINS==
|PDB= 1pho |SIZE=350|CAPTION= <scene name='initialview01'>1pho</scene>, resolution 3.0&Aring;
<StructureSection load='1pho' size='340' side='right'caption='[[1pho]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND=  
<table><tr><td colspan='2'>[[1pho]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PHO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PHO FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
|GENE=  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pho OCA], [https://pdbe.org/1pho PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pho RCSB], [https://www.ebi.ac.uk/pdbsum/1pho PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pho ProSAT]</span></td></tr>
}}
</table>
== Function ==
[https://www.uniprot.org/uniprot/PHOE_ECOLI PHOE_ECOLI] Uptake of inorganic phosphate, phosphorylated compounds, and some other negatively charged solutes.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ph/1pho_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pho ConSurf].
<div style="clear:both"></div>


'''CRYSTAL STRUCTURES EXPLAIN FUNCTIONAL PROPERTIES OF TWO E. COLI PORINS'''
==See Also==
 
*[[Porin 3D structures|Porin 3D structures]]
 
__TOC__
==Overview==
</StructureSection>
Porins form aqueous channels that aid the diffusion of small hydrophilic molecules across the outer membrane of Gram-negative bacteria. The crystal structures of matrix porin and phosphoporin both reveal trimers of identical subunits, each subunit consisting of a 16-stranded anti-parallel beta-barrel containing a pore. A long loop inside the barrel contributes to a constriction of the channel where the charge distribution affects ion selectivity. The structures explain at the molecular level functional characteristics and their alterations by known mutations.
 
==About this Structure==
1PHO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PHO OCA].
 
==Reference==
Crystal structures explain functional properties of two E. coli porins., Cowan SW, Schirmer T, Rummel G, Steiert M, Ghosh R, Pauptit RA, Jansonius JN, Rosenbusch JP, Nature. 1992 Aug 27;358(6389):727-33. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1380671 1380671]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Cowan, S W.]]
[[Category: Cowan SW]]
[[Category: Jansonius, J N.]]
[[Category: Jansonius JN]]
[[Category: Schirmer, T.]]
[[Category: Schirmer T]]
[[Category: outer membrane protein]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:24:31 2008''

Latest revision as of 11:08, 14 February 2024

CRYSTAL STRUCTURES EXPLAIN FUNCTIONAL PROPERTIES OF TWO E. COLI PORINSCRYSTAL STRUCTURES EXPLAIN FUNCTIONAL PROPERTIES OF TWO E. COLI PORINS

Structural highlights

1pho is a 1 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PHOE_ECOLI Uptake of inorganic phosphate, phosphorylated compounds, and some other negatively charged solutes.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1pho, resolution 3.00Å

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