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[[Image:1pgw.jpg|left|200px]]


{{Structure
==BEAN POD MOTTLE VIRUS (BPMV), TOP COMPONENT==
|PDB= 1pgw |SIZE=350|CAPTION= <scene name='initialview01'>1pgw</scene>, resolution 2.90&Aring;
<StructureSection load='1pgw' size='340' side='right'caption='[[1pgw]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND=  
<table><tr><td colspan='2'>[[1pgw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bean-pod_mottle_virus_(strain_Kentucky_G7) Bean-pod mottle virus (strain Kentucky G7)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PGW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PGW FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
|GENE=  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pgw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pgw OCA], [https://pdbe.org/1pgw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pgw RCSB], [https://www.ebi.ac.uk/pdbsum/1pgw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pgw ProSAT]</span></td></tr>
}}
</table>
== Function ==
[https://www.uniprot.org/uniprot/POL2_BPMV POL2_BPMV] Movement protein: transports viral genome to neighboring plant cells directly through plasmosdesmata, without any budding. The movement protein allows efficient cell to cell propagation, by bypassing the host cell wall barrier. Acts by forming a tubular structure at the host plasmodesmata, enlarging it enough to allow free passage of virion capsids (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pg/1pgw_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pgw ConSurf].
<div style="clear:both"></div>


'''BEAN POD MOTTLE VIRUS (BPMV), TOP COMPONENT'''
==See Also==
 
*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
 
__TOC__
==Overview==
</StructureSection>
Ordered nucleic acid in an icosahedral virus was first visualized in the X-ray structure of the Picorna-like plant virus, Bean pod mottle virus (BPMV). Virus particles containing the 3500 nucleotide segment of the BPMV bipartite RNA genome (middle component) had nearly 20% of the genome ordered. Here we report the refined structures of the middle component, bottom component (particles containing the 5800 nucleotide segment of the genome), and top component (empty particles of BPMV capsid protein). The bottom component particles contain ordered RNA in the same location as middle component. Although the ordered RNA density in both nucleoprotein particles is the average of the contents of 60 icosahedral asymmetric units, both nucleoprotein components show that the base density for the first two nucleotides is predominantly purine, while the next five appear to be predominantly pyrimidine. The empty capsid demonstrates that RNA dictates the order of the N-terminal 19 residues of the large subunit because these residues are invisible in the top component.
[[Category: Large Structures]]
 
[[Category: Cavarelli J]]
==About this Structure==
[[Category: Johnson JE]]
1PGW is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Bean_pod_mottle_virus Bean pod mottle virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PGW OCA].
[[Category: Lin T]]
 
==Reference==
Evidence for assembly-dependent folding of protein and RNA in an icosahedral virus., Lin T, Cavarelli J, Johnson JE, Virology. 2003 Sep 15;314(1):26-33. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14517057 14517057]
[[Category: Bean pod mottle virus]]
[[Category: Protein complex]]
[[Category: Cavarelli, J.]]
[[Category: Johnson, J E.]]
[[Category: Lin, T.]]
[[Category: bean pod mottle virus (bpmv)]]
[[Category: comovirus]]
[[Category: icosahedral virus]]
[[Category: viral coat protein]]
[[Category: virus]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:24:15 2008''

Latest revision as of 11:07, 14 February 2024

BEAN POD MOTTLE VIRUS (BPMV), TOP COMPONENTBEAN POD MOTTLE VIRUS (BPMV), TOP COMPONENT

Structural highlights

1pgw is a 2 chain structure with sequence from Bean-pod mottle virus (strain Kentucky G7). Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.9Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

POL2_BPMV Movement protein: transports viral genome to neighboring plant cells directly through plasmosdesmata, without any budding. The movement protein allows efficient cell to cell propagation, by bypassing the host cell wall barrier. Acts by forming a tubular structure at the host plasmodesmata, enlarging it enough to allow free passage of virion capsids (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1pgw, resolution 2.90Å

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