1pdu: Difference between revisions

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<StructureSection load='1pdu' size='340' side='right'caption='[[1pdu]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='1pdu' size='340' side='right'caption='[[1pdu]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1pdu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PDU OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1PDU FirstGlance]. <br>
<table><tr><td colspan='2'>[[1pdu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PDU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PDU FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HR38 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1pdu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pdu OCA], [http://pdbe.org/1pdu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1pdu RCSB], [http://www.ebi.ac.uk/pdbsum/1pdu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1pdu ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pdu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pdu OCA], [https://pdbe.org/1pdu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pdu RCSB], [https://www.ebi.ac.uk/pdbsum/1pdu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pdu ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/HR38_DROME HR38_DROME]] Binds to NGFI-B response elements. Plays an important role in late stages of epidermal metamorphosis.  
[https://www.uniprot.org/uniprot/HR38_DROME HR38_DROME] Binds to NGFI-B response elements. Plays an important role in late stages of epidermal metamorphosis.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pdu ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pdu ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Ecdysteroid pulses trigger the major developmental transitions during the Drosophila life cycle. These hormonal responses are thought to be mediated by the ecdysteroid receptor (EcR) and its heterodimeric partner Ultraspiracle (USP). We provide evidence for a second ecdysteroid signaling pathway mediated by DHR38, the Drosophila ortholog of the mammalian NGFI-B subfamily of orphan nuclear receptors. DHR38 also heterodimerizes with USP, and this complex responds to a distinct class of ecdysteroids in a manner that is independent of EcR. This response is unusual in that it does not involve direct binding of ecdysteroids to either DHR38 or USP. X-ray crystallographic analysis of DHR38 reveals the absence of both a classic ligand binding pocket and coactivator binding site, features that seem to be common to all NGFI-B subfamily members. Taken together, these data reveal the existence of a separate structural class of nuclear receptors that is conserved from fly to humans.
The Drosophila orphan nuclear receptor DHR38 mediates an atypical ecdysteroid signaling pathway.,Baker KD, Shewchuk LM, Kozlova T, Makishima M, Hassell A, Wisely B, Caravella JA, Lambert MH, Reinking JL, Krause H, Thummel CS, Willson TM, Mangelsdorf DJ Cell. 2003 Jun 13;113(6):731-42. PMID:12809604<ref>PMID:12809604</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1pdu" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Drome]]
[[Category: Drosophila melanogaster]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Baker, K D]]
[[Category: Baker KD]]
[[Category: Caravella, J A]]
[[Category: Caravella JA]]
[[Category: Hassell, A M]]
[[Category: Hassell AM]]
[[Category: Korlova, T]]
[[Category: Korlova T]]
[[Category: Lambert, M H]]
[[Category: Lambert MH]]
[[Category: Makishima, M]]
[[Category: Makishima M]]
[[Category: Mangelsdorf, D J]]
[[Category: Mangelsdorf DJ]]
[[Category: Shewchuk, L M]]
[[Category: Shewchuk LM]]
[[Category: Wilson, T M]]
[[Category: Wilson TM]]
[[Category: Wisely, B]]
[[Category: Wisely B]]
[[Category: Hormone-growth factor receptor complex]]
[[Category: Ligand-binding domain]]
[[Category: Nuclear receptor]]

Latest revision as of 11:07, 14 February 2024

Ligand-binding domain of Drosophila orphan nuclear receptor DHR38Ligand-binding domain of Drosophila orphan nuclear receptor DHR38

Structural highlights

1pdu is a 2 chain structure with sequence from Drosophila melanogaster. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.3Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

HR38_DROME Binds to NGFI-B response elements. Plays an important role in late stages of epidermal metamorphosis.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

1pdu, resolution 2.30Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
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