1pdu: Difference between revisions

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[[Image:1pdu.gif|left|200px]]


{{Structure
==Ligand-binding domain of Drosophila orphan nuclear receptor DHR38==
|PDB= 1pdu |SIZE=350|CAPTION= <scene name='initialview01'>1pdu</scene>, resolution 2.3&Aring;
<StructureSection load='1pdu' size='340' side='right'caption='[[1pdu]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND=  
<table><tr><td colspan='2'>[[1pdu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PDU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PDU FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
|GENE= HR38 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 Drosophila melanogaster])
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pdu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pdu OCA], [https://pdbe.org/1pdu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pdu RCSB], [https://www.ebi.ac.uk/pdbsum/1pdu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pdu ProSAT]</span></td></tr>
|DOMAIN=
</table>
|RELATEDENTRY=
== Function ==
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pdu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pdu OCA], [http://www.ebi.ac.uk/pdbsum/1pdu PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1pdu RCSB]</span>
[https://www.uniprot.org/uniprot/HR38_DROME HR38_DROME] Binds to NGFI-B response elements. Plays an important role in late stages of epidermal metamorphosis.
}}
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
'''Ligand-binding domain of Drosophila orphan nuclear receptor DHR38'''
Check<jmol>
 
  <jmolCheckbox>
 
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pd/1pdu_consurf.spt"</scriptWhenChecked>
==Overview==
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
Ecdysteroid pulses trigger the major developmental transitions during the Drosophila life cycle. These hormonal responses are thought to be mediated by the ecdysteroid receptor (EcR) and its heterodimeric partner Ultraspiracle (USP). We provide evidence for a second ecdysteroid signaling pathway mediated by DHR38, the Drosophila ortholog of the mammalian NGFI-B subfamily of orphan nuclear receptors. DHR38 also heterodimerizes with USP, and this complex responds to a distinct class of ecdysteroids in a manner that is independent of EcR. This response is unusual in that it does not involve direct binding of ecdysteroids to either DHR38 or USP. X-ray crystallographic analysis of DHR38 reveals the absence of both a classic ligand binding pocket and coactivator binding site, features that seem to be common to all NGFI-B subfamily members. Taken together, these data reveal the existence of a separate structural class of nuclear receptors that is conserved from fly to humans.
    <text>to colour the structure by Evolutionary Conservation</text>
 
  </jmolCheckbox>
==About this Structure==
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pdu ConSurf].
1PDU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PDU OCA].  
<div style="clear:both"></div>
 
__TOC__
==Reference==
</StructureSection>
The Drosophila orphan nuclear receptor DHR38 mediates an atypical ecdysteroid signaling pathway., Baker KD, Shewchuk LM, Kozlova T, Makishima M, Hassell A, Wisely B, Caravella JA, Lambert MH, Reinking JL, Krause H, Thummel CS, Willson TM, Mangelsdorf DJ, Cell. 2003 Jun 13;113(6):731-42. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12809604 12809604]
[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Baker, K D.]]
[[Category: Baker KD]]
[[Category: Caravella, J A.]]
[[Category: Caravella JA]]
[[Category: Hassell, A M.]]
[[Category: Hassell AM]]
[[Category: Korlova, T.]]
[[Category: Korlova T]]
[[Category: Lambert, M H.]]
[[Category: Lambert MH]]
[[Category: Makishima, M.]]
[[Category: Makishima M]]
[[Category: Mangelsdorf, D J.]]
[[Category: Mangelsdorf DJ]]
[[Category: Shewchuk, L M.]]
[[Category: Shewchuk LM]]
[[Category: Wilson, T M.]]
[[Category: Wilson TM]]
[[Category: Wisely, B.]]
[[Category: Wisely B]]
[[Category: ligand-binding domain]]
[[Category: nuclear receptor]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:58:21 2008''

Latest revision as of 11:07, 14 February 2024

Ligand-binding domain of Drosophila orphan nuclear receptor DHR38Ligand-binding domain of Drosophila orphan nuclear receptor DHR38

Structural highlights

1pdu is a 2 chain structure with sequence from Drosophila melanogaster. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.3Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

HR38_DROME Binds to NGFI-B response elements. Plays an important role in late stages of epidermal metamorphosis.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

1pdu, resolution 2.30Å

Drag the structure with the mouse to rotate

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OCA
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