1pdn: Difference between revisions

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 <StructureSection load='1pdn' size='340' side='right'caption='[[1pdn]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1pdn]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PDN OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1PDN FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1pdn]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PDN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PDN FirstGlance]. <br>
-</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PRD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1pdn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pdn OCA], [http://pdbe.org/1pdn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1pdn RCSB], [http://www.ebi.ac.uk/pdbsum/1pdn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1pdn ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pdn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pdn OCA], [https://pdbe.org/1pdn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pdn RCSB], [https://www.ebi.ac.uk/pdbsum/1pdn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pdn ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/PRD_DROME PRD_DROME]] Pair-rule protein expressed in a segmentally repeating pattern to define the polarity of embryonic segments. Capable of sequence-specific DNA-binding.
+[https://www.uniprot.org/uniprot/PRD_DROME PRD_DROME] Pair-rule protein expressed in a segmentally repeating pattern to define the polarity of embryonic segments. Capable of sequence-specific DNA-binding.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
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 </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pdn ConSurf].
 <div style="clear:both"></div>
-<div style="background-color:#fffaf0;">
-== Publication Abstract from PubMed ==
-The 2.5 A resolution structure of a cocrystal containing the paired domain from the Drosophila paired (prd) protein and a 15 bp site shows structurally independent N-terminal and C-terminal subdomains. Each of these domains contains a helical region resembling the homeodomain and the Hin recombinase. The N-terminal domain makes extensive DNA contacts, using a novel beta turn motif that binds in the minor groove and a helix-turn-helix unit with a docking arrangement surprisingly similar to that of the lambda repressor. The C-terminal domain is not essential for prd binding and does not contact the optimized site. All known developmental missense mutations in the paired box of mammalian Pax genes map to the N-terminal subdomain, and most of them are found at the protein-DNA interface.
-Crystal structure of a paired domain-DNA complex at 2.5 A resolution reveals structural basis for Pax developmental mutations.,Xu W, Rould MA, Jun S, Desplan C, Pabo CO Cell. 1995 Feb 24;80(4):639-50. PMID:7867071<ref>PMID:7867071</ref>
-From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-</div>
-<div class="pdbe-citations 1pdn" style="background-color:#fffaf0;"></div>
-== References ==
-<references/>
 __TOC__
 </StructureSection>
-[[Category: Drome]]
+[[Category: Drosophila melanogaster]]
 [[Category: Large Structures]]
-[[Category: Desplan, C]]
+[[Category: Desplan C]]
-[[Category: Jun, S]]
+[[Category: Jun S]]
-[[Category: Pabo, C O]]
+[[Category: Pabo CO]]
-[[Category: Rould, M A]]
+[[Category: Rould MA]]
-[[Category: Xu, W]]
+[[Category: Xu W]]
-[[Category: Dna-binding protein]]
-[[Category: Double helix]]
-[[Category: Gene regulation-dna complex]]
-[[Category: Paired domain]]
-[[Category: Pax]]
-[[Category: Prd]]
-[[Category: Protein-dna complex]]