1ozp: Difference between revisions

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[[Image:1ozp.png|left|200px]]


{{STRUCTURE_1ozp|  PDB=1ozp  |  SCENE=  }}
==Crystal Structure of Rv0819 from Mycobacterium tuberculosis MshD-Mycothiol Synthase Acetyl-Coenzyme A Complex.==
 
<StructureSection load='1ozp' size='340' side='right'caption='[[1ozp]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
===Crystal Structure of Rv0819 from Mycobacterium tuberculosis MshD-Mycothiol Synthase Acetyl-Coenzyme A Complex.===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1ozp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OZP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OZP FirstGlance]. <br>
{{ABSTRACT_PUBMED_12930994}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ozp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ozp OCA], [https://pdbe.org/1ozp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ozp RCSB], [https://www.ebi.ac.uk/pdbsum/1ozp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ozp ProSAT]</span></td></tr>
[[1ozp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OZP OCA].  
</table>
 
== Function ==
==Reference==
[https://www.uniprot.org/uniprot/MSHD_MYCTU MSHD_MYCTU] Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.<ref>PMID:12375100</ref>
<ref group="xtra">PMID:012930994</ref><references group="xtra"/>
== Evolutionary Conservation ==
[[Category: Mycobacterium tuberculosis]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: Blanchard, J S.]]
Check<jmol>
[[Category: Roderick, S L.]]
  <jmolCheckbox>
[[Category: Vetting, M W.]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oz/1ozp_consurf.spt"</scriptWhenChecked>
[[Category: Yu, M.]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: Acetyl coenzyme a complex]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: Acetyltransferase]]
  </jmolCheckbox>
[[Category: Gnat fold]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ozp ConSurf].
[[Category: Mshd]]
<div style="clear:both"></div>
[[Category: Transferase]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Blanchard JS]]
[[Category: Roderick SL]]
[[Category: Vetting MW]]
[[Category: Yu M]]

Latest revision as of 11:04, 14 February 2024

Crystal Structure of Rv0819 from Mycobacterium tuberculosis MshD-Mycothiol Synthase Acetyl-Coenzyme A Complex.Crystal Structure of Rv0819 from Mycobacterium tuberculosis MshD-Mycothiol Synthase Acetyl-Coenzyme A Complex.

Structural highlights

1ozp is a 1 chain structure with sequence from Mycobacterium tuberculosis H37Rv. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.7Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

MSHD_MYCTU Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Koledin T, Newton GL, Fahey RC. Identification of the mycothiol synthase gene (mshD) encoding the acetyltransferase producing mycothiol in actinomycetes. Arch Microbiol. 2002 Nov;178(5):331-7. Epub 2002 Aug 15. PMID:12375100 doi:http://dx.doi.org/10.1007/s00203-002-0462-y

1ozp, resolution 1.70Å

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OCA
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