1oy8: Difference between revisions

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-{{Seed}}
-[[Image:1oy8.png|left|200px]]
-<!--
+==Structural Basis of Multiple Drug Binding Capacity of the AcrB Multidrug Efflux Pump==
-The line below this paragraph, containing "STRUCTURE_1oy8", creates the "Structure Box" on the page.
+<StructureSection load='1oy8' size='340' side='right'caption='[[1oy8]], [[Resolution|resolution]] 3.63&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1oy8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. The November 2007 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Multidrug Resistance Transporters''  by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2007_11 10.2210/rcsb_pdb/mom_2007_11]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OY8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OY8 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.63&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RHQ:RHODAMINE+6G'>RHQ</scene></td></tr>
-{{STRUCTURE_1oy8|  PDB=1oy8  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oy8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oy8 OCA], [https://pdbe.org/1oy8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oy8 RCSB], [https://www.ebi.ac.uk/pdbsum/1oy8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oy8 ProSAT]</span></td></tr>
+</table>
-===Structural Basis of Multiple Drug Binding Capacity of the AcrB Multidrug Efflux Pump===
+== Function ==
+[https://www.uniprot.org/uniprot/ACRB_ECOLI ACRB_ECOLI] AcrAB is a drug efflux protein with a broad substrate specificity.<ref>PMID:16915237</ref> <ref>PMID:16946072</ref> <ref>PMID:17194213</ref>
+== Evolutionary Conservation ==
-<!--
+[[Image:Consurf_key_small.gif|200px|right]]
-The line below this paragraph, {{ABSTRACT_PUBMED_12738864}}, adds the Publication Abstract to the page
+Check<jmol>
-(as it appears on PubMed at http://www.pubmed.gov), where 12738864 is the PubMed ID number.
+  <jmolCheckbox>
--->
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oy/1oy8_consurf.spt"</scriptWhenChecked>
-{{ABSTRACT_PUBMED_12738864}}
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
-==About this Structure==
+  </jmolCheckbox>
-OY8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Additional information on 1OY8 is available in a page on [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb95_1.html Multidrug Resistance Transporters] at the RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OY8 OCA].
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1oy8 ConSurf].
+<div style="clear:both"></div>
-==Reference==
+== References ==
-Structural basis of multiple drug-binding capacity of the AcrB multidrug efflux pump., Yu EW, McDermott G, Zgurskaya HI, Nikaido H, Koshland DE Jr, Science. 2003 May 9;300(5621):976-80. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12738864 12738864]
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Escherichia coli]]
+[[Category: Large Structures]]
 [[Category: Multidrug Resistance Transporters]]
-[[Category: Single protein]]
+[[Category: RCSB PDB Molecule of the Month]]
-[[Category: Jr., D E.Koshland.]]
+[[Category: Koshland Jr DE]]
-[[Category: McDermott, G.]]
+[[Category: McDermott G]]
-[[Category: Nikaido, H.]]
+[[Category: Nikaido H]]
-[[Category: Yu, E W.]]
+[[Category: Yu EW]]
-[[Category: Zgurskaya, H I.]]
+[[Category: Zgurskaya HI]]
-[[Category: Membrane protein]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 23 10:58:02 2008''