1oty: Difference between revisions

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-{{Seed}}
-[[Image:1oty.png|left|200px]]
-<!--
+==Native PNP +ALLO==
-The line below this paragraph, containing "STRUCTURE_1oty", creates the "Structure Box" on the page.
+<StructureSection load='1oty' size='340' side='right'caption='[[1oty]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1oty]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OTY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OTY FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6MP:6-METHYLPURINE'>6MP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-{{STRUCTURE_1oty|  PDB=1oty  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oty FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oty OCA], [https://pdbe.org/1oty PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oty RCSB], [https://www.ebi.ac.uk/pdbsum/1oty PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oty ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/DEOD_ECOLI DEOD_ECOLI] Cleavage of guanosine or inosine to respective bases and sugar-1-phosphate molecules.[HAMAP-Rule:MF_01627]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ot/1oty_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1oty ConSurf].
+<div style="clear:both"></div>
-===Native PNP +ALLO===
+==See Also==
+*[[Purine nucleoside phosphorylase 3D structures|Purine nucleoside phosphorylase 3D structures]]
+__TOC__
-<!--
+</StructureSection>
-The line below this paragraph, {{ABSTRACT_PUBMED_14700625}}, adds the Publication Abstract to the page
-(as it appears on PubMed at http://www.pubmed.gov), where 14700625 is the PubMed ID number.
--->
-{{ABSTRACT_PUBMED_14700625}}
-==About this Structure==
-OTY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OTY OCA].
-==Reference==
-Designer gene therapy using an Escherichia coli purine nucleoside phosphorylase/prodrug system., Bennett EM, Anand R, Allan PW, Hassan AE, Hong JS, Levasseur DN, McPherson DT, Parker WB, Secrist JA 3rd, Sorscher EJ, Townes TM, Waud WR, Ealick SE, Chem Biol. 2003 Dec;10(12):1173-81. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14700625 14700625]
 [[Category: Escherichia coli]]
-[[Category: Purine-nucleoside phosphorylase]]
+[[Category: Large Structures]]
-[[Category: Single protein]]
+[[Category: Allan PW]]
-[[Category: Allan, P W.]]
+[[Category: Anand R]]
-[[Category: Anand, R.]]
+[[Category: Bennett EM]]
-[[Category: Bennett, E M.]]
+[[Category: Ealick SE]]
-[[Category: Ealick, S E.]]
+[[Category: Hassan AE]]
-[[Category: Hassan, A E.]]
+[[Category: McPherson DT]]
-[[Category: McPherson, D T.]]
+[[Category: Parker WB]]
-[[Category: Parker, W B.]]
+[[Category: Secrist JA]]
-[[Category: Secrist, J A.]]
+[[Category: Sorscher EJ]]
-[[Category: Sorscher, E J.]]
-[[Category: Glycosyltransferase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:39:23 2008''