1oct: Difference between revisions

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-[[Image:1oct.png|left|200px]]
-{{STRUCTURE_1oct|  PDB=1oct  |  SCENE=  }}
+==CRYSTAL STRUCTURE OF THE OCT-1 POU DOMAIN BOUND TO AN OCTAMER SITE: DNA RECOGNITION WITH TETHERED DNA-BINDING MODULES==
+<StructureSection load='1oct' size='340' side='right'caption='[[1oct]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
-===CRYSTAL STRUCTURE OF THE OCT-1 POU DOMAIN BOUND TO AN OCTAMER SITE: DNA RECOGNITION WITH TETHERED DNA-BINDING MODULES===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1oct]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OCT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OCT FirstGlance]. <br>
-{{ABSTRACT_PUBMED_8156594}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oct FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oct OCA], [https://pdbe.org/1oct PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oct RCSB], [https://www.ebi.ac.uk/pdbsum/1oct PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oct ProSAT]</span></td></tr>
-==About this Structure==
+</table>
-[[1oct]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OCT OCA].
+== Function ==
+[https://www.uniprot.org/uniprot/PO2F1_HUMAN PO2F1_HUMAN] Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR (By similarity). In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes.<ref>PMID:1684878</ref>
-==See Also==
+== Evolutionary Conservation ==
-*[[Intrinsically Disordered Protein|Intrinsically Disordered Protein]]
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
-==Reference==
+  <jmolCheckbox>
-<ref group="xtra">PMID:008156594</ref><ref group="xtra">PMID:011258480</ref><references group="xtra"/>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oc/1oct_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1oct ConSurf].
+<div style="clear:both"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Aurora, R.]]
+[[Category: Large Structures]]
-[[Category: Herr, W.]]
+[[Category: Aurora R]]
-[[Category: Klemm, J D.]]
+[[Category: Herr W]]
-[[Category: Pabo, C O.]]
+[[Category: Klemm JD]]
-[[Category: Rould, M A.]]
+[[Category: Pabo CO]]
-[[Category: Protein-dna complex]]
+[[Category: Rould MA]]
-[[Category: Transcription-dna complex]]