1nyc: Difference between revisions

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{{Seed}}
[[Image:1nyc.png|left|200px]]


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==Staphostatins resemble lipocalins, not cystatins in fold.==
The line below this paragraph, containing "STRUCTURE_1nyc", creates the "Structure Box" on the page.
<StructureSection load='1nyc' size='340' side='right'caption='[[1nyc]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1nyc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_MW2 Staphylococcus aureus subsp. aureus MW2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NYC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NYC FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
{{STRUCTURE_1nyc|  PDB=1nyc  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nyc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nyc OCA], [https://pdbe.org/1nyc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nyc RCSB], [https://www.ebi.ac.uk/pdbsum/1nyc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nyc ProSAT]</span></td></tr>
 
</table>
===Staphostatins resemble lipocalins, not cystatins in fold.===
== Function ==
 
[https://www.uniprot.org/uniprot/SSPC_STAAW SSPC_STAAW] Specifically inhibits the cysteine protease staphopain B (SspB) by blocking the active site of the enzyme. Probably required to protect cytoplasmic proteins from being degraded by prematurely activated/folded prostaphopain B. Also involved in growth capacity, viability and bacterial morphology (By similarity).
 
__TOC__
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</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_14500882}}, adds the Publication Abstract to the page
[[Category: Large Structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 14500882 is the PubMed ID number.
[[Category: Staphylococcus aureus subsp. aureus MW2]]
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[[Category: Bochtler M]]
{{ABSTRACT_PUBMED_14500882}}
[[Category: Dubin A]]
 
[[Category: Filipek R]]
==About this Structure==
[[Category: Kosowska K]]
1NYC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NYC OCA].  
[[Category: Potempa J]]
 
[[Category: Rzychon M]]
==Reference==
[[Category: Sabat A]]
Staphostatins resemble lipocalins, not cystatins in fold., Rzychon M, Filipek R, Sabat A, Kosowska K, Dubin A, Potempa J, Bochtler M, Protein Sci. 2003 Oct;12(10):2252-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14500882 14500882]
[[Category: Single protein]]
[[Category: Staphylococcus aureus]]
[[Category: Bochtler, M.]]
[[Category: Dubin, A.]]
[[Category: Filipek, R.]]
[[Category: Kosowska, K.]]
[[Category: Potempa, J.]]
[[Category: Rzychon, M.]]
[[Category: Sabat, A.]]
[[Category: Cysteine protease inhibitor]]
[[Category: Sspc]]
[[Category: Staphostatin b]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:36:48 2008''

Latest revision as of 11:00, 14 February 2024

Staphostatins resemble lipocalins, not cystatins in fold.Staphostatins resemble lipocalins, not cystatins in fold.

Structural highlights

1nyc is a 2 chain structure with sequence from Staphylococcus aureus subsp. aureus MW2. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.4Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SSPC_STAAW Specifically inhibits the cysteine protease staphopain B (SspB) by blocking the active site of the enzyme. Probably required to protect cytoplasmic proteins from being degraded by prematurely activated/folded prostaphopain B. Also involved in growth capacity, viability and bacterial morphology (By similarity).

1nyc, resolution 1.40Å

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