1nx3: Difference between revisions

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[[Image:1nx3.png|left|200px]]


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==Calpain Domain VI in Complex with the Inhibitor PD150606==
The line below this paragraph, containing "STRUCTURE_1nx3", creates the "Structure Box" on the page.
<StructureSection load='1nx3' size='340' side='right'caption='[[1nx3]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1nx3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NX3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NX3 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ISA:3-(4-IODO-PHENYL)-2-MERCAPTO-PROPIONIC+ACID'>ISA</scene></td></tr>
{{STRUCTURE_1nx3| PDB=1nx3 |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nx3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nx3 OCA], [https://pdbe.org/1nx3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nx3 RCSB], [https://www.ebi.ac.uk/pdbsum/1nx3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nx3 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CPNS1_PIG CPNS1_PIG] Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nx/1nx3_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nx3 ConSurf].
<div style="clear:both"></div>


===Calpain Domain VI in Complex with the Inhibitor PD150606===
==See Also==
 
*[[Calpain 3D structures|Calpain 3D structures]]
 
__TOC__
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</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_12684003}}, adds the Publication Abstract to the page
[[Category: Large Structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 12684003 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12684003}}
 
==About this Structure==
1NX3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NX3 OCA].
 
==Reference==
A structural model for the inhibition of calpain by calpastatin: crystal structures of the native domain VI of calpain and its complexes with calpastatin peptide and a small molecule inhibitor., Todd B, Moore D, Deivanayagam CC, Lin GD, Chattopadhyay D, Maki M, Wang KK, Narayana SV, J Mol Biol. 2003 Apr 18;328(1):131-46. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12684003 12684003]
[[Category: Hydrolase]]
[[Category: Single protein]]
[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
[[Category: Chattopadhyay, D.]]
[[Category: Chattopadhyay D]]
[[Category: Deivanayagam, C C.S.]]
[[Category: Deivanayagam CCS]]
[[Category: Lin, G D.]]
[[Category: Lin G-D]]
[[Category: Maki, M.]]
[[Category: Maki M]]
[[Category: Moore, D.]]
[[Category: Moore D]]
[[Category: Narayana, S V.L.]]
[[Category: Narayana SVL]]
[[Category: Todd, B.]]
[[Category: Todd B]]
[[Category: Wang, K K.W.]]
[[Category: Wang KKW]]
[[Category: Calcium binding]]
[[Category: Hydrolase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:18:19 2008''

Latest revision as of 11:00, 14 February 2024

Calpain Domain VI in Complex with the Inhibitor PD150606Calpain Domain VI in Complex with the Inhibitor PD150606

Structural highlights

1nx3 is a 1 chain structure with sequence from Sus scrofa. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.45Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CPNS1_PIG Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1nx3, resolution 2.45Å

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