1ntb: Difference between revisions

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[[Image:1ntb.gif|left|200px]]


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==2.9 A crystal structure of Streptomycin RNA-aptamer complex==
The line below this paragraph, containing "STRUCTURE_1ntb", creates the "Structure Box" on the page.
<StructureSection load='1ntb' size='340' side='right'caption='[[1ntb]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1ntb]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NTB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NTB FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SRY:STREPTOMYCIN'>SRY</scene></td></tr>
{{STRUCTURE_1ntb|  PDB=1ntb  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ntb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ntb OCA], [https://pdbe.org/1ntb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ntb RCSB], [https://www.ebi.ac.uk/pdbsum/1ntb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ntb ProSAT]</span></td></tr>
 
</table>
'''2.9 A crystal structure of Streptomycin RNA-aptamer complex'''
__TOC__
 
</StructureSection>
 
[[Category: Large Structures]]
==Overview==
[[Category: Patel DJ]]
We describe a 2.9 A X-ray structure of a complex between the aminocyclitol antibiotic streptomycin and an in vitro selected RNA aptamer, solved using the anomalous diffraction properties of Ba cations. The RNA aptamer, which contains two asymmetric internal loops, adopts a distinct cation-stabilized fold involving a series of S-shaped backbone turns anchored by canonical and noncanonical pairs and triples. The streptomycin streptose ring is encapsulated by stacked arrays of bases from both loops at the elbow of the L-shaped RNA architecture. Specificity is defined by direct hydrogen bonds between all streptose functional groups and base edges that line the inner walls of the cylindrical binding pocket. By contrast, the majority of intermolecular interactions involve contacts to backbone phosphates in the published structure of streptomycin bound to the 16S rRNA.
[[Category: Skripkin E]]
 
[[Category: Tereshko V]]
==About this Structure==
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NTB OCA].  
 
==Reference==
Encapsulating streptomycin within a small 40-mer RNA., Tereshko V, Skripkin E, Patel DJ, Chem Biol. 2003 Feb;10(2):175-87. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12618190 12618190]
[[Category: Patel, D J.]]
[[Category: Skripkin, E.]]
[[Category: Tereshko, V.]]
[[Category: Magnesium form]]
[[Category: Streptomycin rna-aptamer]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 02:57:16 2008''

Latest revision as of 10:59, 14 February 2024

2.9 A crystal structure of Streptomycin RNA-aptamer complex2.9 A crystal structure of Streptomycin RNA-aptamer complex

Structural highlights

1ntb is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.9Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

1ntb, resolution 2.90Å

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