1nn4: Difference between revisions

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[[Image:1nn4.png|left|200px]]


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==Structural Genomics, RpiB/AlsB==
The line below this paragraph, containing "STRUCTURE_1nn4", creates the "Structure Box" on the page.
<StructureSection load='1nn4' size='340' side='right'caption='[[1nn4]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1nn4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NN4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NN4 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nn4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nn4 OCA], [https://pdbe.org/1nn4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nn4 RCSB], [https://www.ebi.ac.uk/pdbsum/1nn4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nn4 ProSAT], [https://www.topsan.org/Proteins/MCSG/1nn4 TOPSAN]</span></td></tr>
{{STRUCTURE_1nn4| PDB=1nn4 |  SCENE= }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/RPIB_ECOLI RPIB_ECOLI] In addition to its activity on D-ribose 5-phosphate it probably also has activity on D-allose 6-phosphate.<ref>PMID:8576032</ref> <ref>PMID:4909663</ref> <ref>PMID:1104357</ref> <ref>PMID:9401019</ref> <ref>PMID:18640127</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nn/1nn4_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nn4 ConSurf].
<div style="clear:both"></div>


===Structural Genomics, RpiB/AlsB===
==See Also==
 
*[[Ribose-5-phosphate isomerase 3D structures|Ribose-5-phosphate isomerase 3D structures]]
 
== References ==
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{{ABSTRACT_PUBMED_14499611}}
 
==About this Structure==
1NN4 is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NN4 OCA].
 
==Reference==
The 2.2 A resolution structure of RpiB/AlsB from Escherichia coli illustrates a new approach to the ribose-5-phosphate isomerase reaction., Zhang RG, Andersson CE, Skarina T, Evdokimova E, Edwards AM, Joachimiak A, Savchenko A, Mowbray SL, J Mol Biol. 2003 Oct 3;332(5):1083-94. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14499611 14499611]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Ribose-5-phosphate isomerase]]
[[Category: Large Structures]]
[[Category: Andersson, C E.]]
[[Category: Andersson CE]]
[[Category: Arrowsmith, C.]]
[[Category: Arrowsmith C]]
[[Category: Beasley, S L.]]
[[Category: Beasley SL]]
[[Category: Edwards, A M.]]
[[Category: Edwards AM]]
[[Category: Evdokimova, E.]]
[[Category: Evdokimova E]]
[[Category: Joachimiak, A.]]
[[Category: Joachimiak A]]
[[Category: MCSG, Midwest Center for Structural Genomics.]]
[[Category: Mowbray SL]]
[[Category: Mowbray, S L.]]
[[Category: Savchenko A]]
[[Category: Savchenko, A.]]
[[Category: Skarina T]]
[[Category: Skarina, T.]]
[[Category: Zhang RG]]
[[Category: Zhang, R G.]]
[[Category: Alpha/beta/alpha sandwich]]
[[Category: Mcsg]]
[[Category: Midwest center for structural genomic]]
[[Category: Protein structure initiative]]
[[Category: Psi]]
[[Category: Structural genomic]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Nov 16 17:05:49 2008''

Latest revision as of 10:57, 14 February 2024

Structural Genomics, RpiB/AlsBStructural Genomics, RpiB/AlsB

Structural highlights

1nn4 is a 4 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.2Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

RPIB_ECOLI In addition to its activity on D-ribose 5-phosphate it probably also has activity on D-allose 6-phosphate.[1] [2] [3] [4] [5]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Sorensen KI, Hove-Jensen B. Ribose catabolism of Escherichia coli: characterization of the rpiB gene encoding ribose phosphate isomerase B and of the rpiR gene, which is involved in regulation of rpiB expression. J Bacteriol. 1996 Feb;178(4):1003-11. PMID:8576032
  2. ↑ David J, Wiesmeyer H. Regulation of ribose metabolism in Escherichia coli. II. Evidence for two ribose-5-phosphate isomerase activities. Biochim Biophys Acta. 1970 Apr 14;208(1):56-67. PMID:4909663
  3. ↑ Essenberg MK, Cooper RA. Two ribose-5-phosphate isomerases from Escherichia coli K12: partial characterisation of the enzymes and consideration of their possible physiological roles. Eur J Biochem. 1975 Jul 1;55(2):323-32. PMID:1104357
  4. ↑ Kim C, Song S, Park C. The D-allose operon of Escherichia coli K-12. J Bacteriol. 1997 Dec;179(24):7631-7. PMID:9401019
  5. ↑ Roos AK, Mariano S, Kowalinski E, Salmon L, Mowbray SL. D-ribose-5-phosphate isomerase B from Escherichia coli is also a functional D-allose-6-phosphate isomerase, while the Mycobacterium tuberculosis enzyme is not. J Mol Biol. 2008 Oct 10;382(3):667-79. Epub 2008 Jul 9. PMID:18640127 doi:10.1016/j.jmb.2008.06.090

1nn4, resolution 2.20Å

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