1ngm: Difference between revisions

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-{{Seed}}
-[[Image:1ngm.png|left|200px]]
-<!--
+==Crystal structure of a yeast Brf1-TBP-DNA ternary complex==
-The line below this paragraph, containing "STRUCTURE_1ngm", creates the "Structure Box" on the page.
+<StructureSection load='1ngm' size='340' side='right'caption='[[1ngm]], [[Resolution|resolution]] 2.95&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1ngm]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NGM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NGM FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.95&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ngm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ngm OCA], [https://pdbe.org/1ngm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ngm RCSB], [https://www.ebi.ac.uk/pdbsum/1ngm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ngm ProSAT]</span></td></tr>
-{{STRUCTURE_1ngm|  PDB=1ngm  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/TBP_YEAST TBP_YEAST] General transcription factor that functions at the core of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.<ref>PMID:9618449</ref> <ref>PMID:12138208</ref> <ref>PMID:12516863</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ng/1ngm_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ngm ConSurf].
+<div style="clear:both"></div>
-===Crystal structure of a yeast Brf1-TBP-DNA ternary complex===
+==See Also==
+*[[TATA-binding protein 3D structures|TATA-binding protein 3D structures]]
+== References ==
-<!--
+<references/>
-The line below this paragraph, {{ABSTRACT_PUBMED_12660736}}, adds the Publication Abstract to the page
+__TOC__
-(as it appears on PubMed at http://www.pubmed.gov), where 12660736 is the PubMed ID number.
+</StructureSection>
--->
+[[Category: Large Structures]]
-{{ABSTRACT_PUBMED_12660736}}
-==About this Structure==
-NGM is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NGM OCA].
-==Reference==
-Crystal structure of a transcription factor IIIB core interface ternary complex., Juo ZS, Kassavetis GA, Wang J, Geiduschek EP, Sigler PB, Nature. 2003 Apr 3;422(6931):534-9. Epub 2003 Mar 26. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12660736 12660736]
-[[Category: Protein complex]]
 [[Category: Saccharomyces cerevisiae]]
-[[Category: Geiduschek, E P.]]
+[[Category: Geiduschek EP]]
-[[Category: Juo, Z S.]]
+[[Category: Juo ZS]]
-[[Category: Kassavetis, G A.]]
+[[Category: Kassavetis GA]]
-[[Category: Sigler, P B.]]
+[[Category: Sigler PB]]
-[[Category: Wang, J.]]
+[[Category: Wang J]]
-[[Category: Brf]]
-[[Category: Brf1]]
-[[Category: Protein-dna complex]]
-[[Category: Taf]]
-[[Category: Tbp]]
-[[Category: Tfiiib]]
-[[Category: Transcription]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:54:17 2008''