1ngm: Difference between revisions

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[[Image:1ngm.png|left|200px]]


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==Crystal structure of a yeast Brf1-TBP-DNA ternary complex==
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<StructureSection load='1ngm' size='340' side='right'caption='[[1ngm]], [[Resolution|resolution]] 2.95&Aring;' scene=''>
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== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1ngm]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NGM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NGM FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.95&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ngm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ngm OCA], [https://pdbe.org/1ngm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ngm RCSB], [https://www.ebi.ac.uk/pdbsum/1ngm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ngm ProSAT]</span></td></tr>
{{STRUCTURE_1ngm|  PDB=1ngm  |  SCENE=  }}
</table>
 
== Function ==
===Crystal structure of a yeast Brf1-TBP-DNA ternary complex===
[https://www.uniprot.org/uniprot/TBP_YEAST TBP_YEAST] General transcription factor that functions at the core of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.<ref>PMID:9618449</ref> <ref>PMID:12138208</ref> <ref>PMID:12516863</ref>
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ng/1ngm_consurf.spt"</scriptWhenChecked>
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==About this Structure==
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ngm ConSurf].
[[1ngm]] is a 16 chain structure of [[TATA-Binding Protein]] with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NGM OCA].  
<div style="clear:both"></div>


==See Also==
==See Also==
*[[TATA-Binding Protein]]
*[[TATA-binding protein 3D structures|TATA-binding protein 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:12660736</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Geiduschek, E P.]]
[[Category: Geiduschek EP]]
[[Category: Juo, Z S.]]
[[Category: Juo ZS]]
[[Category: Kassavetis, G A.]]
[[Category: Kassavetis GA]]
[[Category: Sigler, P B.]]
[[Category: Sigler PB]]
[[Category: Wang, J.]]
[[Category: Wang J]]
[[Category: Brf]]
[[Category: Brf1]]
[[Category: Protein-dna complex]]
[[Category: Taf]]
[[Category: Tbp]]
[[Category: Tfiiib]]
[[Category: Transcription]]
[[Category: Transcription/dna complex]]

Latest revision as of 10:56, 14 February 2024

Crystal structure of a yeast Brf1-TBP-DNA ternary complexCrystal structure of a yeast Brf1-TBP-DNA ternary complex

Structural highlights

1ngm is a 16 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.95Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TBP_YEAST General transcription factor that functions at the core of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.[1] [2] [3]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Hampsey M. Molecular genetics of the RNA polymerase II general transcriptional machinery. Microbiol Mol Biol Rev. 1998 Jun;62(2):465-503. PMID:9618449
  2. ↑ Sanders SL, Garbett KA, Weil PA. Molecular characterization of Saccharomyces cerevisiae TFIID. Mol Cell Biol. 2002 Aug;22(16):6000-13. PMID:12138208
  3. ↑ Martinez E. Multi-protein complexes in eukaryotic gene transcription. Plant Mol Biol. 2002 Dec;50(6):925-47. PMID:12516863

1ngm, resolution 2.95Å

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