1ne8: Difference between revisions

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-{{Seed}}
-[[Image:1ne8.png|left|200px]]
-<!--
+==YDCE protein from Bacillus subtilis==
-The line below this paragraph, containing "STRUCTURE_1ne8", creates the "Structure Box" on the page.
+<StructureSection load='1ne8' size='340' side='right'caption='[[1ne8]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1ne8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NE8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NE8 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PG:2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL'>1PG</scene>, <scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene></td></tr>
-{{STRUCTURE_1ne8|  PDB=1ne8  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ne8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ne8 OCA], [https://pdbe.org/1ne8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ne8 RCSB], [https://www.ebi.ac.uk/pdbsum/1ne8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ne8 ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/1ne8 TOPSAN]</span></td></tr>
+</table>
-===YDCE protein from Bacillus subtilis===
+== Function ==
+[https://www.uniprot.org/uniprot/ENDOA_BACSU ENDOA_BACSU] Toxic component of a toxin-antitoxin (TA) module. Has specificity for UACAU sequences, claving after the first U and yielding cleavage products with 3' phosphate and 5' hydroxyl groups. Overexpression is toxic for cell growth, probably by inhibiting protein synthesis through the cleavage of single-stranded RNA. The toxicity is reversed by the antitoxin EndoAI. Toxin activity cannot be inhibited by MazE from E.coli.<ref>PMID:15882409</ref> <ref>PMID:21763692</ref>
+== Evolutionary Conservation ==
-==About this Structure==
+[[Image:Consurf_key_small.gif|200px|right]]
-NE8 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NE8 OCA].
+Check<jmol>
+  <jmolCheckbox>
-==Reference==
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ne/1ne8_consurf.spt"</scriptWhenChecked>
-Crystal structure of YdcE protein from Bacillus subtilis., Gogos A, Mu H, Bahna F, Gomez CA, Shapiro L, Proteins. 2003 Nov 1;53(2):320-2. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14517982 14517982]
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ne8 ConSurf].
+<div style="clear:both"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Bacillus subtilis]]
-[[Category: Bahna, F.]]
+[[Category: Large Structures]]
-[[Category: Burley, S K.]]
+[[Category: Bahna F]]
-[[Category: Gogos, A.]]
+[[Category: Burley SK]]
-[[Category: Gomez, C A.]]
+[[Category: Gogos A]]
-[[Category: Mu, H.]]
+[[Category: Gomez CA]]
-[[Category: NYSGXRC, New York Structural GenomiX Research Consortium.]]
+[[Category: Mu H]]
-[[Category: Shapiro, L.]]
+[[Category: Shapiro L]]
-[[Category: Conserved hypothetical protein ydce]]
-[[Category: New york structural genomix research consortium]]
-[[Category: Nysgxrc]]
-[[Category: Protein structure initiative]]
-[[Category: Psi]]
-[[Category: Structural genomic]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Nov 16 10:07:14 2008''