1ne8: Difference between revisions

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-[[Image:1ne8.gif|left|200px]]
- {{Structure
+==YDCE protein from Bacillus subtilis==
-|PDB= 1ne8 |SIZE=350|CAPTION= <scene name='initialview01'>1ne8</scene>, resolution 2.1&Aring;
+<StructureSection load='1ne8' size='340' side='right'caption='[[1ne8]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND= <scene name='pdbligand=1PG:2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL'>1PG</scene>, <scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>
+<table><tr><td colspan='2'>[[1ne8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NE8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NE8 FirstGlance]. <br>
-|ACTIVITY=
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-|GENE= ydcE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus subtilis])
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PG:2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL'>1PG</scene>, <scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene></td></tr>
-|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam02452 PemK]</span>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ne8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ne8 OCA], [https://pdbe.org/1ne8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ne8 RCSB], [https://www.ebi.ac.uk/pdbsum/1ne8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ne8 ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/1ne8 TOPSAN]</span></td></tr>
-|RELATEDENTRY=
+</table>
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ne8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ne8 OCA], [http://www.ebi.ac.uk/pdbsum/1ne8 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ne8 RCSB]</span>
+== Function ==
-}}
+[https://www.uniprot.org/uniprot/ENDOA_BACSU ENDOA_BACSU] Toxic component of a toxin-antitoxin (TA) module. Has specificity for UACAU sequences, claving after the first U and yielding cleavage products with 3' phosphate and 5' hydroxyl groups. Overexpression is toxic for cell growth, probably by inhibiting protein synthesis through the cleavage of single-stranded RNA. The toxicity is reversed by the antitoxin EndoAI. Toxin activity cannot be inhibited by MazE from E.coli.<ref>PMID:15882409</ref> <ref>PMID:21763692</ref>
+== Evolutionary Conservation ==
-'''YDCE protein from Bacillus subtilis'''
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
-==About this Structure==
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ne/1ne8_consurf.spt"</scriptWhenChecked>
-NE8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NE8 OCA].
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
-==Reference==
+  </jmolCheckbox>
-Crystal structure of YdcE protein from Bacillus subtilis., Gogos A, Mu H, Bahna F, Gomez CA, Shapiro L, Proteins. 2003 Nov 1;53(2):320-2. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14517982 14517982]
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ne8 ConSurf].
+<div style="clear:both"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Bacillus subtilis]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Bahna, F.]]
+[[Category: Bahna F]]
-[[Category: Burley, S K.]]
+[[Category: Burley SK]]
-[[Category: Gogos, A.]]
+[[Category: Gogos A]]
-[[Category: Gomez, C A.]]
+[[Category: Gomez CA]]
-[[Category: Mu, H.]]
+[[Category: Mu H]]
-[[Category: NYSGXRC, New York Structural GenomiX Research Consortium.]]
+[[Category: Shapiro L]]
-[[Category: Shapiro, L.]]
-[[Category: conserved hypothetical protein ydce]]
-[[Category: new york structural genomix research consortium]]
-[[Category: nysgxrc]]
-[[Category: protein structure initiative]]
-[[Category: psi]]
-[[Category: structural genomic]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:29:10 2008''