1n9a: Difference between revisions

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-{{Seed}}
-[[Image:1n9a.png|left|200px]]
-<!--
+==Farnesyltransferase complex with tetrahydropyridine inhibitors==
-The line below this paragraph, containing "STRUCTURE_1n9a", creates the "Structure Box" on the page.
+<StructureSection load='1n9a' size='340' side='right'caption='[[1n9a]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1n9a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N9A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N9A FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FTI:1-{2-[3-(4-CYANO-BENZYL)-3H-IMIDAZOL-4-YL]-ACETYL}-5-NAPHTHALEN-1-YL-1,2,3,6-TETRAHYDRO-PYRIDINE-4-CARBONITRILE'>FTI</scene>, <scene name='pdbligand=HFP:ALPHA-HYDROXYFARNESYLPHOSPHONIC+ACID'>HFP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-{{STRUCTURE_1n9a|  PDB=1n9a  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n9a OCA], [https://pdbe.org/1n9a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n9a RCSB], [https://www.ebi.ac.uk/pdbsum/1n9a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n9a ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/FNTA_RAT FNTA_RAT] Catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. The alpha subunit is thought to participate in a stable complex with the substrate. The beta subunit binds the peptide substrate. Through RAC1 prenylation and activation may positively regulate neuromuscular junction development downstream of MUSK (By similarity).
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n9/1n9a_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n9a ConSurf].
+<div style="clear:both"></div>
-===Farnesyltransferase complex with tetrahydropyridine inhibitors===
+==See Also==
+*[[Farnesyltransferase 3D structures|Farnesyltransferase 3D structures]]
+__TOC__
-<!--
+</StructureSection>
-The line below this paragraph, {{ABSTRACT_PUBMED_12657283}}, adds the Publication Abstract to the page
+[[Category: Large Structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 12657283 is the PubMed ID number.
--->
-{{ABSTRACT_PUBMED_12657283}}
-==About this Structure==
-N9A is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N9A OCA].
-==Reference==
-<ref group="xtra">PMID:12657283</ref><references group="xtra"/>
 [[Category: Rattus norvegicus]]
-[[Category: Cohen, J.]]
+[[Category: Cohen J]]
-[[Category: Conner, S J.O.]]
+[[Category: Gu WZ]]
-[[Category: Gu, W Z.]]
+[[Category: Gwaltney II SL]]
-[[Category: Hasvold, L.]]
+[[Category: Hasvold L]]
-[[Category: II, S L.Gwaltney.]]
+[[Category: Imade H]]
-[[Category: Imade, H.]]
+[[Category: Li Q]]
-[[Category: Li, Q.]]
+[[Category: Nelson LT]]
-[[Category: Nelson, L T.]]
+[[Category: O'Conner SJ]]
-[[Category: Sullivan, G M.]]
+[[Category: Sullivan GM]]
-[[Category: Wang, W.]]
+[[Category: Wang W]]
-[[Category: Farnesyltransferase]]
-[[Category: Prenyltransferase]]
-[[Category: Tetrahydropyridine]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 11:28:27 2009''