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[[Image:1n7a.gif|left|200px]]


{{Structure
==RIP-Radiation-damage Induced Phasing==
|PDB= 1n7a |SIZE=350|CAPTION= <scene name='initialview01'>1n7a</scene>, resolution 1.20&Aring;
<StructureSection load='1n7a' size='340' side='right'caption='[[1n7a]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=BGM:8-BROMO-2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>BGM</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=SPM:SPERMINE'>SPM</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
<table><tr><td colspan='2'>[[1n7a]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N7A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N7A FirstGlance]. <br>
|ACTIVITY=
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2&#8491;</td></tr>
|GENE=
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGM:8-BROMO-2-DEOXYGUANOSINE-5-MONOPHOSPHATE'>BGM</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=SPM:SPERMINE'>SPM</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n7a OCA], [https://pdbe.org/1n7a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n7a RCSB], [https://www.ebi.ac.uk/pdbsum/1n7a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n7a ProSAT]</span></td></tr>
|RELATEDENTRY=[[1n7b|1N7B]], [[1n6x|1N6X]], [[1n6y|1N6Y]]
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n7a OCA], [http://www.ebi.ac.uk/pdbsum/1n7a PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1n7a RCSB]</span>
__TOC__
}}
</StructureSection>
 
[[Category: Large Structures]]
'''RIP-Radiation-damage Induced Phasing'''
[[Category: Caffrey M]]
 
[[Category: Leiros H-KS]]
 
[[Category: McSweeney S]]
==Overview==
[[Category: Pan B]]
The use of third generation synchrotron sources has led to renewed concern about the effect of ionizing radiation on crystalline biological samples. In general, the problem is seen as one to be avoided. However, in this paper, it is shown that, far from being a hindrance to successful structure determination, radiation damage provides an opportunity for phasing macromolecular structures. This is successfully demonstrated for both a protein and an oligonucleotide, by way of which complete models were built automatically. The possibility that, through the exploitation of radiation damage, the phase problem could become less of a barrier to macromolecular crystal structure determination is discussed.
[[Category: Ravelli RBG]]
 
==About this Structure==
1N7A is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N7A OCA].
 
==Reference==
Specific radiation damage can be used to solve macromolecular crystal structures., Ravelli RB, Leiros HK, Pan B, Caffrey M, McSweeney S, Structure. 2003 Feb;11(2):217-24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12575941 12575941]
[[Category: Protein complex]]
[[Category: Caffrey, M.]]
[[Category: Leiros, H K.S.]]
[[Category: McSweeney, S.]]
[[Category: Pan, B.]]
[[Category: Ravelli, R B.G.]]
[[Category: dna]]
[[Category: rna]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:26:23 2008''

Latest revision as of 10:53, 14 February 2024

RIP-Radiation-damage Induced PhasingRIP-Radiation-damage Induced Phasing

Structural highlights

1n7a is a 8 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.2Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

1n7a, resolution 1.20Å

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