1n6b: Difference between revisions

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[[Image:1n6b.png|left|200px]]


{{STRUCTURE_1n6b|  PDB=1n6b  |  SCENE=  }}
==Microsomal Cytochrome P450 2C5/3LVdH Complex with a dimethyl derivative of sulfaphenazole==
 
<StructureSection load='1n6b' size='340' side='right'caption='[[1n6b]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
===Microsomal Cytochrome P450 2C5/3LVdH Complex with a dimethyl derivative of sulfaphenazole===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1n6b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N6B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N6B FirstGlance]. <br>
{{ABSTRACT_PUBMED_12767218}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMZ:4-METHYL-N-METHYL-N-(2-PHENYL-2H-PYRAZOL-3-YL)BENZENESULFONAMIDE'>DMZ</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n6b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n6b OCA], [https://pdbe.org/1n6b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n6b RCSB], [https://www.ebi.ac.uk/pdbsum/1n6b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n6b ProSAT]</span></td></tr>
[[1n6b]] is a 1 chain structure of [[Cytochrome P450]] with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N6B OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/CP2C5_RABIT CP2C5_RABIT] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n6/1n6b_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n6b ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Cytochrome P450|Cytochrome P450]]
*[[Cytochrome P450 3D structures|Cytochrome P450 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:012767218</ref><references group="xtra"/>
[[Category: Large Structures]]
[[Category: Oryctolagus cuniculus]]
[[Category: Oryctolagus cuniculus]]
[[Category: Unspecific monooxygenase]]
[[Category: Dansette PM]]
[[Category: Dansette, P M.]]
[[Category: Johnson EF]]
[[Category: Johnson, E F.]]
[[Category: Mansuy D]]
[[Category: Mansuy, D.]]
[[Category: Marques-Soares C]]
[[Category: Marques-Soares, C.]]
[[Category: Stout CD]]
[[Category: Stout, C D.]]
[[Category: Wester MR]]
[[Category: Wester, M R.]]
[[Category: Cyp2c5]]
[[Category: Dimethylsulfaphenazole complex]]
[[Category: Estradiol 2-hydroxylase]]
[[Category: Membrane protein]]
[[Category: Oxidoreductase]]
[[Category: P450]]
[[Category: Progesterone 21-hydroxylase]]
[[Category: Pyrene hydroxylase]]

Latest revision as of 10:53, 14 February 2024

Microsomal Cytochrome P450 2C5/3LVdH Complex with a dimethyl derivative of sulfaphenazoleMicrosomal Cytochrome P450 2C5/3LVdH Complex with a dimethyl derivative of sulfaphenazole

Structural highlights

1n6b is a 1 chain structure with sequence from Oryctolagus cuniculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.3Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CP2C5_RABIT Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1n6b, resolution 2.30Å

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OCA
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