1n67: Difference between revisions

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[[Image:1n67.png|left|200px]]


{{STRUCTURE_1n67| PDB=1n67 | SCENE= }}
==Clumping Factor A from Staphylococcus aureus==
<StructureSection load='1n67' size='340' side='right'caption='[[1n67]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1n67]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N67 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N67 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n67 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n67 OCA], [https://pdbe.org/1n67 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n67 RCSB], [https://www.ebi.ac.uk/pdbsum/1n67 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n67 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CLFA_STAAE CLFA_STAAE] Cell surface-associated protein implicated in virulence. Promotes bacterial attachment exclusively to the gamma-chain of human fibrinogen. Induces formation of bacterial clumps, which diminish the ability of group IIA phospholipase A2 to cause bacterial phospholipid hydrolysis and killing. Significantly decreases macrophage phagocytosis possibly thanks to the clumps, clumped bacteria being too large to be phagocytosed. Dominant factor responsible for human platelet aggregation, which may be an important mechanism for initiating infective endocarditis. Enhances spleen cell proliferative response in vitro, contributing significantly to the immunostimulatory activity of S.aureus.<ref>PMID:10225887</ref> <ref>PMID:11292731</ref> <ref>PMID:12010496</ref> <ref>PMID:14998517</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n6/1n67_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n67 ConSurf].
<div style="clear:both"></div>


===Clumping Factor A from Staphylococcus aureus===
==See Also==
 
*[[Fibrinogen binding protein|Fibrinogen binding protein]]
{{ABSTRACT_PUBMED_12485987}}
== References ==
 
<references/>
==About this Structure==
__TOC__
[[1n67]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N67 OCA].
</StructureSection>
 
[[Category: Large Structures]]
==Reference==
<ref group="xtra">PMID:012485987</ref><references group="xtra"/>
[[Category: Staphylococcus aureus]]
[[Category: Carson, M.]]
[[Category: Chen, W.]]
[[Category: Deivanayagam, C C.S.]]
[[Category: Hook, M.]]
[[Category: Narayana, S V.L.]]
[[Category: Rajashankar, K R.]]
[[Category: Wann, E R.]]
[[Category: Cell adhesion]]
[[Category: Clumping factor]]
[[Category: Dev-igg]]
[[Category: Fibrinongen-binding]]
[[Category: Igg]]
[[Category: Igsf]]
[[Category: Immunoglobulin]]
[[Category: Staphylococcus aureus]]
[[Category: Staphylococcus aureus]]
[[Category: Carson M]]
[[Category: Chen W]]
[[Category: Deivanayagam CCS]]
[[Category: Hook M]]
[[Category: Narayana SVL]]
[[Category: Rajashankar KR]]
[[Category: Wann ER]]

Latest revision as of 10:53, 14 February 2024

Clumping Factor A from Staphylococcus aureusClumping Factor A from Staphylococcus aureus

Structural highlights

1n67 is a 1 chain structure with sequence from Staphylococcus aureus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.9Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CLFA_STAAE Cell surface-associated protein implicated in virulence. Promotes bacterial attachment exclusively to the gamma-chain of human fibrinogen. Induces formation of bacterial clumps, which diminish the ability of group IIA phospholipase A2 to cause bacterial phospholipid hydrolysis and killing. Significantly decreases macrophage phagocytosis possibly thanks to the clumps, clumped bacteria being too large to be phagocytosed. Dominant factor responsible for human platelet aggregation, which may be an important mechanism for initiating infective endocarditis. Enhances spleen cell proliferative response in vitro, contributing significantly to the immunostimulatory activity of S.aureus.[1] [2] [3] [4]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Dominiecki ME, Weiss J. Antibacterial action of extracellular mammalian group IIA phospholipase A2 against grossly clumped Staphylococcus aureus. Infect Immun. 1999 May;67(5):2299-305. PMID:10225887
  2. ↑ Siboo IR, Cheung AL, Bayer AS, Sullam PM. Clumping factor A mediates binding of Staphylococcus aureus to human platelets. Infect Immun. 2001 May;69(5):3120-7. PMID:11292731 doi:http://dx.doi.org/10.1128/IAI.69.5.3120-3127.2001
  3. ↑ O'Brien L, Kerrigan SW, Kaw G, Hogan M, Penades J, Litt D, Fitzgerald DJ, Foster TJ, Cox D. Multiple mechanisms for the activation of human platelet aggregation by Staphylococcus aureus: roles for the clumping factors ClfA and ClfB, the serine-aspartate repeat protein SdrE and protein A. Mol Microbiol. 2002 May;44(4):1033-44. PMID:12010496
  4. ↑ Palmqvist N, Patti JM, Tarkowski A, Josefsson E. Expression of staphylococcal clumping factor A impedes macrophage phagocytosis. Microbes Infect. 2004 Feb;6(2):188-95. PMID:14998517 doi:http://dx.doi.org/10.1016/j.micinf.2003.11.005

1n67, resolution 1.90Å

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