1myt: Difference between revisions

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[[Image:1myt.gif|left|200px]]


{{Structure
==CRYSTAL STRUCTURE TO 1.74 ANGSTROMS RESOLUTION OF METMYOGLOBIN FROM YELLOWFIN TUNA (THUNNUS ALBACARES): AN EXAMPLE OF A MYOGLOBIN LACKING THE D HELIX==
|PDB= 1myt |SIZE=350|CAPTION= <scene name='initialview01'>1myt</scene>, resolution 1.74&Aring;
<StructureSection load='1myt' size='340' side='right'caption='[[1myt]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>
<table><tr><td colspan='2'>[[1myt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thunnus_albacares Thunnus albacares]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MYT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MYT FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.74&#8491;</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1myt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1myt OCA], [https://pdbe.org/1myt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1myt RCSB], [https://www.ebi.ac.uk/pdbsum/1myt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1myt ProSAT]</span></td></tr>
|RELATEDENTRY=
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1myt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1myt OCA], [http://www.ebi.ac.uk/pdbsum/1myt PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1myt RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/MYG_THUAL MYG_THUAL] Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/my/1myt_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1myt ConSurf].
<div style="clear:both"></div>


'''CRYSTAL STRUCTURE TO 1.74 ANGSTROMS RESOLUTION OF METMYOGLOBIN FROM YELLOWFIN TUNA (THUNNUS ALBACARES): AN EXAMPLE OF A MYOGLOBIN LACKING THE D HELIX'''
==See Also==
 
*[[Myoglobin 3D structures|Myoglobin 3D structures]]
 
__TOC__
==Overview==
</StructureSection>
The crystal structure of metmyoglobin from yellowfin tuna (Thunnus albacares) has been determined by molecular replacement methods and refined to a conventional R factor of 0.177 for all observed reflections in the range of 6.0-1.70 A resolution. Like other myoglobins for which a high-resolution structure is available, the polypeptide chain is organized into several helices that cooperate to form a hydrophobic pocket into which the heme prosthetic group is non-covalently bound; however, the D helix observed in other myoglobins is absent in myoglobin from yellowfin tuna and has been replaced with a random coil. As well, the A helix has a pronounced kink due to the presence of Pro16. The differences in structure between this and sperm whale myoglobin can be correlated with their reported dioxygen affinity and dissociation. The structure is in agreement with reported fluorescence data which show an increased Trp14.heme distance in yellowfin tuna compared to sperm whale myoglobin.
[[Category: Large Structures]]
 
==About this Structure==
1MYT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thunnus_albacares Thunnus albacares]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MYT OCA].
 
==Reference==
1.70 A resolution structure of myoglobin from yellowfin tuna. An example of a myoglobin lacking the D helix., Birnbaum GI, Evans SV, Przybylska M, Rose DR, Acta Crystallogr D Biol Crystallogr. 1994 May 1;50(Pt 3):283-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15299440 15299440]
[[Category: Single protein]]
[[Category: Thunnus albacares]]
[[Category: Thunnus albacares]]
[[Category: Birnbaum, G I.]]
[[Category: Birnbaum GI]]
[[Category: Evans, S V.]]
[[Category: Evans SV]]
[[Category: Przybylska, M.]]
[[Category: Przybylska M]]
[[Category: Rose, D R.]]
[[Category: Rose DR]]
[[Category: oxygen transport]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:23:01 2008''

Latest revision as of 10:50, 14 February 2024

CRYSTAL STRUCTURE TO 1.74 ANGSTROMS RESOLUTION OF METMYOGLOBIN FROM YELLOWFIN TUNA (THUNNUS ALBACARES): AN EXAMPLE OF A MYOGLOBIN LACKING THE D HELIXCRYSTAL STRUCTURE TO 1.74 ANGSTROMS RESOLUTION OF METMYOGLOBIN FROM YELLOWFIN TUNA (THUNNUS ALBACARES): AN EXAMPLE OF A MYOGLOBIN LACKING THE D HELIX

Structural highlights

1myt is a 1 chain structure with sequence from Thunnus albacares. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.74Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

MYG_THUAL Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1myt, resolution 1.74Å

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