1muk: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1muk.gif|left|200px]]
- {{Structure
+==reovirus lambda3 native structure==
-|PDB= 1muk |SIZE=350|CAPTION= <scene name='initialview01'>1muk</scene>, resolution 2.50&Aring;
+<StructureSection load='1muk' size='340' side='right'caption='[[1muk]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND=
+<table><tr><td colspan='2'>[[1muk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Reovirus_sp. Reovirus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MUK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MUK FirstGlance]. <br>
-|ACTIVITY=
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
-|GENE= L1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10891 Reovirus sp.])
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1muk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1muk OCA], [https://pdbe.org/1muk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1muk RCSB], [https://www.ebi.ac.uk/pdbsum/1muk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1muk ProSAT]</span></td></tr>
-|DOMAIN=
+</table>
-|RELATEDENTRY=
+== Function ==
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1muk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1muk OCA], [http://www.ebi.ac.uk/pdbsum/1muk PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1muk RCSB]</span>
+[https://www.uniprot.org/uniprot/RDRP_REOVD RDRP_REOVD] RNA-directed RNA polymerase that is involved in transcription and genome replication. Following infection, it catalyzes the synthesis of fully conservative plus strands. After core assembly, which consists in recruitment of one capped plus-strand for each genomic segments and polymerase complexes, the polymerase switches mode and catalyzes the synthesis of complementary minus-strands.
-}}
-'''reovirus lambda3 native structure'''
+==See Also==
+*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
+__TOC__
-==Overview==
+</StructureSection>
-The reovirus polymerase and those of other dsRNA viruses function within the confines of a protein capsid to transcribe the tightly packed dsRNA genome segments. The crystal structure of the reovirus polymerase, lambda3, determined at 2.5 A resolution, shows a fingers-palm-thumb core, similar to those of other viral polymerases, surrounded by major N- and C-terminal elaborations, which create a cage-like structure, with four channels leading to the catalytic site. This "caged" polymerase has allowed us to visualize the results of several rounds of RNA polymerization directly in the crystals. A 5' cap binding site on the surface of lambda3 suggests a template retention mechanism by which attachment of the 5' end of the plus-sense strand facilitates insertion of the 3' end of the minus-sense strand into the template channel.
+[[Category: Large Structures]]
+[[Category: Reovirus sp]]
-==About this Structure==
+[[Category: Farsetta DL]]
-MUK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Reovirus_sp. Reovirus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MUK OCA].
+[[Category: Harrison SC]]
+[[Category: Nibert ML]]
-==Reference==
+[[Category: Tao Y]]
-RNA synthesis in a cage--structural studies of reovirus polymerase lambda3., Tao Y, Farsetta DL, Nibert ML, Harrison SC, Cell. 2002 Nov 27;111(5):733-45. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12464184 12464184]
-[[Category: Reovirus sp.]]
-[[Category: Single protein]]
-[[Category: Farsetta, D L.]]
-[[Category: Harrison, S C.]]
-[[Category: Nibert, M L.]]
-[[Category: Tao, Y.]]
-[[Category: finger]]
-[[Category: palm]]
-[[Category: right hand configuration]]
-[[Category: single subunit polymerase fold]]
-[[Category: thumb]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:21:17 2008''