1mto: Difference between revisions

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-[[Image:1mto.png|left|200px]]
-{{STRUCTURE_1mto|  PDB=1mto  |  SCENE=  }}
+==Crystal structure of a Phosphofructokinase mutant from Bacillus stearothermophilus bound with fructose-6-phosphate==
+<StructureSection load='1mto' size='340' side='right'caption='[[1mto]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
-===Crystal structure of a Phosphofructokinase mutant from Bacillus stearothermophilus bound with fructose-6-phosphate===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1mto]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MTO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MTO FirstGlance]. <br>
-{{ABSTRACT_PUBMED_12390023}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=F6P:FRUCTOSE-6-PHOSPHATE'>F6P</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mto FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mto OCA], [https://pdbe.org/1mto PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mto RCSB], [https://www.ebi.ac.uk/pdbsum/1mto PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mto ProSAT]</span></td></tr>
-[[1mto]] is a 8 chain structure of [[Phosphofructokinase (PFK)]] with sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MTO OCA].
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PFKA_GEOSE PFKA_GEOSE] Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.[HAMAP-Rule:MF_00339]<ref>PMID:8136379</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mt/1mto_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mto ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Phosphofructokinase (PFK)|Phosphofructokinase (PFK)]]
+*[[Phosphofructokinase 3D structures|Phosphofructokinase 3D structures]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:012390023</ref><references group="xtra"/>
+__TOC__
-[[Category: 6-phosphofructokinase]]
+</StructureSection>
 [[Category: Geobacillus stearothermophilus]]
-[[Category: Reinhart, G D.]]
+[[Category: Large Structures]]
-[[Category: Riley-Lovingshimer, M R.]]
+[[Category: Reinhart GD]]
-[[Category: Ronning, D R.]]
+[[Category: Riley-Lovingshimer MR]]
-[[Category: Sacchettini, J C.]]
+[[Category: Ronning DR]]
-[[Category: Fructose-6-phosphate]]
+[[Category: Sacchettini JC]]
-[[Category: Phosphofructokinase]]
-[[Category: Transferase]]
-[[Category: Tryptophan-shift]]