1mj2: Difference between revisions

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-{{Seed}}
-[[Image:1mj2.png|left|200px]]
-<!--
+==METHIONINE REPRESSOR MUTANT (Q44K) PLUS COREPRESSOR (S-ADENOSYL METHIONINE) COMPLEXED TO A CONSENSUS OPERATOR SEQUENCE==
-The line below this paragraph, containing "STRUCTURE_1mj2", creates the "Structure Box" on the page.
+<StructureSection load='1mj2' size='340' side='right'caption='[[1mj2]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1mj2]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MJ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MJ2 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
-{{STRUCTURE_1mj2|  PDB=1mj2  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mj2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mj2 OCA], [https://pdbe.org/1mj2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mj2 RCSB], [https://www.ebi.ac.uk/pdbsum/1mj2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mj2 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/METJ_ECOLI METJ_ECOLI] This regulatory protein, when combined with SAM (S-adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis. It is also autoregulated.[HAMAP-Rule:MF_00744]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mj/1mj2_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mj2 ConSurf].
+<div style="clear:both"></div>
-===METHIONINE REPRESSOR MUTANT (Q44K) PLUS COREPRESSOR (S-ADENOSYL METHIONINE) COMPLEXED TO A CONSENSUS OPERATOR SEQUENCE===
+==See Also==
+*[[Met repressor|Met repressor]]
+__TOC__
-<!--
+</StructureSection>
-The line below this paragraph, {{ABSTRACT_PUBMED_10986458}}, adds the Publication Abstract to the page
-(as it appears on PubMed at http://www.pubmed.gov), where 10986458 is the PubMed ID number.
--->
-{{ABSTRACT_PUBMED_10986458}}
-==About this Structure==
-MJ2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MJ2 OCA].
-==Reference==
-Direct and indirect readout in mutant Met repressor-operator complexes., Garvie CW, Phillips SE, Structure. 2000 Sep 15;8(9):905-14. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10986458 10986458]
 [[Category: Escherichia coli]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Garvie, C W.]]
+[[Category: Garvie CW]]
-[[Category: Phillips, S E.V.]]
+[[Category: Phillips SEV]]
-[[Category: Dna]]
-[[Category: Methionine repressor]]
-[[Category: Metj]]
-[[Category: S-adenosyl methionine]]
-[[Category: Sheet-helix-helix]]
-[[Category: Transcription regulation]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul  3 00:05:11 2008''