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[[Image:1mix.gif|left|200px]]


{{Structure
==Crystal structure of a FERM domain of Talin==
|PDB= 1mix |SIZE=350|CAPTION= <scene name='initialview01'>1mix</scene>, resolution 1.75&Aring;
<StructureSection load='1mix' size='340' side='right'caption='[[1mix]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND=  
<table><tr><td colspan='2'>[[1mix]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MIX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MIX FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
|GENE=  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mix FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mix OCA], [https://pdbe.org/1mix PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mix RCSB], [https://www.ebi.ac.uk/pdbsum/1mix PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mix ProSAT]</span></td></tr>
|DOMAIN=
</table>
|RELATEDENTRY=[[1miz|1MIZ]], [[1mk7|1MK7]], [[1mk9|1MK9]]
== Function ==
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mix FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mix OCA], [http://www.ebi.ac.uk/pdbsum/1mix PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1mix RCSB]</span>
[https://www.uniprot.org/uniprot/TLN1_CHICK TLN1_CHICK] Probably involved in connections of major cytoskeletal structures to the plasma membrane. Talin is a high molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts.
}}
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mi/1mix_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mix ConSurf].
<div style="clear:both"></div>


'''Crystal structure of a FERM domain of Talin'''
==See Also==
 
*[[Talin 3D structures|Talin 3D structures]]
 
__TOC__
==Overview==
</StructureSection>
The binding of cytoplasmic proteins, such as talin, to the cytoplasmic domains of integrin adhesion receptors mediates bidirectional signal transduction. Here we report the crystal structure of the principal integrin binding and activating fragment of talin, alone and in complex with fragments of the beta 3 integrin tail. The FERM (four point one, ezrin, radixin, and moesin) domain of talin engages integrins via a novel variant of the canonical phosphotyrosine binding (PTB) domain-NPxY ligand interaction that may be a prototype for FERM domain recognition of transmembrane receptors. In combination with NMR and mutational analysis, our studies reveal the critical interacting elements of both talin and the integrin beta 3 tail, providing structural paradigms for integrin linkage to the cell interior.
 
==About this Structure==
1MIX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MIX OCA].
 
==Reference==
Structural determinants of integrin recognition by talin., Garcia-Alvarez B, de Pereda JM, Calderwood DA, Ulmer TS, Critchley D, Campbell ID, Ginsberg MH, Liddington RC, Mol Cell. 2003 Jan;11(1):49-58. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12535520 12535520]
[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Calderwood, D A.]]
[[Category: Calderwood DA]]
[[Category: Campbell, I D.]]
[[Category: Campbell ID]]
[[Category: Critchley, D.]]
[[Category: Critchley D]]
[[Category: Garcia-Alvarez, B.]]
[[Category: Garcia-Alvarez B]]
[[Category: Ginsberg, M H.]]
[[Category: Ginsberg MH]]
[[Category: Liddington, R C.]]
[[Category: Liddington RC]]
[[Category: Pereda, J M.de.]]
[[Category: Ulmer TS]]
[[Category: Ulmer, T S.]]
[[Category: De Pereda JM]]
[[Category: cytoskeleton]]
[[Category: ferm domain]]
[[Category: focal adhesion]]
[[Category: integrin binding]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:16:38 2008''

Latest revision as of 10:44, 14 February 2024

Crystal structure of a FERM domain of TalinCrystal structure of a FERM domain of Talin

Structural highlights

1mix is a 1 chain structure with sequence from Gallus gallus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.75Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TLN1_CHICK Probably involved in connections of major cytoskeletal structures to the plasma membrane. Talin is a high molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1mix, resolution 1.75Å

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