1mep: Difference between revisions

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-[[Image:1mep.png|left|200px]]
-{{STRUCTURE_1mep|  PDB=1mep  |  SCENE=  }}
+==Crystal Structure of Streptavidin Double Mutant S45A/D128A with Biotin: Cooperative Hydrogen-Bond Interactions in the Streptavidin-Biotin System.==
+<StructureSection load='1mep' size='340' side='right'caption='[[1mep]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
-===Crystal Structure of Streptavidin Double Mutant S45A/D128A with Biotin: Cooperative Hydrogen-Bond Interactions in the Streptavidin-Biotin System.===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1mep]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_avidinii Streptomyces avidinii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MEP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MEP FirstGlance]. <br>
-{{ABSTRACT_PUBMED_16452627}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTN:BIOTIN'>BTN</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mep FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mep OCA], [https://pdbe.org/1mep PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mep RCSB], [https://www.ebi.ac.uk/pdbsum/1mep PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mep ProSAT]</span></td></tr>
-[[1mep]] is a 4 chain structure of [[Avidin]] with sequence from [http://en.wikipedia.org/wiki/Streptomyces_avidinii Streptomyces avidinii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MEP OCA].
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/SAV_STRAV SAV_STRAV] The biological function of streptavidin is not known. Forms a strong non-covalent specific complex with biotin (one molecule of biotin per subunit of streptavidin).
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/me/1mep_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mep ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Avidin|Avidin]]
+*[[Avidin 3D structures|Avidin 3D structures]]
+__TOC__
-==Reference==
+</StructureSection>
-<ref group="xtra">PMID:016452627</ref><references group="xtra"/>
+[[Category: Large Structures]]
 [[Category: Streptomyces avidinii]]
-[[Category: Green, N M.]]
+[[Category: Green NM]]
-[[Category: Hyre, D E.]]
+[[Category: Hyre DE]]
-[[Category: Merritt, E A.]]
+[[Category: Le Trong I]]
-[[Category: Stayton, P S.]]
+[[Category: Merritt EA]]
-[[Category: Stenkamp, R E.]]
+[[Category: Stayton PS]]
-[[Category: Trong, I Le.]]
+[[Category: Stenkamp RE]]
-[[Category: Biotin-binding protein]]
-[[Category: Homotetramer]]