1m8e: Difference between revisions

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-{{Seed}}
-[[Image:1m8e.png|left|200px]]
-<!--
+==inducible nitric oxide synthase with 7-nitroindazole bound==
-The line below this paragraph, containing "STRUCTURE_1m8e", creates the "Structure Box" on the page.
+<StructureSection load='1m8e' size='340' side='right'caption='[[1m8e]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1m8e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M8E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M8E FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7NI:7-NITROINDAZOLE'>7NI</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
-{{STRUCTURE_1m8e|  PDB=1m8e  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m8e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m8e OCA], [https://pdbe.org/1m8e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m8e RCSB], [https://www.ebi.ac.uk/pdbsum/1m8e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m8e ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/NOS2_MOUSE NOS2_MOUSE] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.<ref>PMID:16373578</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m8/1m8e_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1m8e ConSurf].
+<div style="clear:both"></div>
-===inducible nitric oxide synthase with 7-nitroindazole bound===
+==See Also==
+*[[Nitric Oxide Synthase 3D structures|Nitric Oxide Synthase 3D structures]]
+== References ==
-<!--
+<references/>
-The line below this paragraph, {{ABSTRACT_PUBMED_12437348}}, adds the Publication Abstract to the page
+__TOC__
-(as it appears on PubMed at http://www.pubmed.gov), where 12437348 is the PubMed ID number.
+</StructureSection>
--->
+[[Category: Large Structures]]
-{{ABSTRACT_PUBMED_12437348}}
-==About this Structure==
-M8E is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M8E OCA].
-==Reference==
-Conformational changes in nitric oxide synthases induced by chlorzoxazone and nitroindazoles: crystallographic and computational analyses of inhibitor potency., Rosenfeld RJ, Garcin ED, Panda K, Andersson G, Aberg A, Wallace AV, Morris GM, Olson AJ, Stuehr DJ, Tainer JA, Getzoff ED, Biochemistry. 2002 Nov 26;41(47):13915-25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12437348 12437348]
 [[Category: Mus musculus]]
-[[Category: Nitric-oxide synthase]]
+[[Category: Aberg A]]
-[[Category: Single protein]]
+[[Category: Andersson G]]
-[[Category: Aberg, A.]]
+[[Category: Garcin ED]]
-[[Category: Andersson, G.]]
+[[Category: Getzoff ED]]
-[[Category: Garcin, E D.]]
+[[Category: Panda K]]
-[[Category: Getzoff, E D.]]
+[[Category: Rosenfeld RJ]]
-[[Category: Panda, K.]]
+[[Category: Stuehr DJ]]
-[[Category: Rosenfeld, R J.]]
+[[Category: Tainer JA]]
-[[Category: Stuehr, D J.]]
+[[Category: Wallace AV]]
-[[Category: Tainer, J A.]]
-[[Category: Wallace, A V.]]
-[[Category: Oxidoreductase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul  2 23:25:50 2008''