1m8e: Difference between revisions

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[[Image:1m8e.png|left|200px]]


{{STRUCTURE_1m8e|  PDB=1m8e  |  SCENE=  }}
==inducible nitric oxide synthase with 7-nitroindazole bound==
 
<StructureSection load='1m8e' size='340' side='right'caption='[[1m8e]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
===inducible nitric oxide synthase with 7-nitroindazole bound===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1m8e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M8E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M8E FirstGlance]. <br>
{{ABSTRACT_PUBMED_12437348}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7NI:7-NITROINDAZOLE'>7NI</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m8e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m8e OCA], [https://pdbe.org/1m8e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m8e RCSB], [https://www.ebi.ac.uk/pdbsum/1m8e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m8e ProSAT]</span></td></tr>
[[1m8e]] is a 2 chain structure of [[Nitric Oxide Synthase]] with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M8E OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/NOS2_MOUSE NOS2_MOUSE] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.<ref>PMID:16373578</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m8/1m8e_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1m8e ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Nitric Oxide Synthase|Nitric Oxide Synthase]]
*[[Nitric Oxide Synthase 3D structures|Nitric Oxide Synthase 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:012437348</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Nitric-oxide synthase]]
[[Category: Aberg A]]
[[Category: Aberg, A.]]
[[Category: Andersson G]]
[[Category: Andersson, G.]]
[[Category: Garcin ED]]
[[Category: Garcin, E D.]]
[[Category: Getzoff ED]]
[[Category: Getzoff, E D.]]
[[Category: Panda K]]
[[Category: Panda, K.]]
[[Category: Rosenfeld RJ]]
[[Category: Rosenfeld, R J.]]
[[Category: Stuehr DJ]]
[[Category: Stuehr, D J.]]
[[Category: Tainer JA]]
[[Category: Tainer, J A.]]
[[Category: Wallace AV]]
[[Category: Wallace, A V.]]
[[Category: Oxidoreductase]]

Latest revision as of 10:41, 14 February 2024

inducible nitric oxide synthase with 7-nitroindazole boundinducible nitric oxide synthase with 7-nitroindazole bound

Structural highlights

1m8e is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.9Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

NOS2_MOUSE Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Kim SF, Huri DA, Snyder SH. Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2. Science. 2005 Dec 23;310(5756):1966-70. PMID:16373578 doi:http://dx.doi.org/10.1126/science.1119407

1m8e, resolution 2.90Å

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