1m8d: Difference between revisions

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-{{Seed}}
-[[Image:1m8d.png|left|200px]]
-<!--
+==inducible nitric oxide synthase with Chlorzoxazone bound==
-The line below this paragraph, containing "STRUCTURE_1m8d", creates the "Structure Box" on the page.
+<StructureSection load='1m8d' size='340' side='right'caption='[[1m8d]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1m8d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M8D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M8D FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=CLW:CHLORZOXAZONE'>CLW</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-{{STRUCTURE_1m8d|  PDB=1m8d  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m8d OCA], [https://pdbe.org/1m8d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m8d RCSB], [https://www.ebi.ac.uk/pdbsum/1m8d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m8d ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/NOS2_MOUSE NOS2_MOUSE] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.<ref>PMID:16373578</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m8/1m8d_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1m8d ConSurf].
+<div style="clear:both"></div>
-===inducible nitric oxide synthase with Chlorzoxazone bound===
+==See Also==
+*[[Nitric Oxide Synthase 3D structures|Nitric Oxide Synthase 3D structures]]
+== References ==
-<!--
+<references/>
-The line below this paragraph, {{ABSTRACT_PUBMED_12437348}}, adds the Publication Abstract to the page
+__TOC__
-(as it appears on PubMed at http://www.pubmed.gov), where 12437348 is the PubMed ID number.
+</StructureSection>
--->
+[[Category: Large Structures]]
-{{ABSTRACT_PUBMED_12437348}}
-==About this Structure==
-M8D is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M8D OCA].
-==Reference==
-<ref group="xtra">PMID:12437348</ref><references group="xtra"/>
 [[Category: Mus musculus]]
-[[Category: Nitric-oxide synthase]]
+[[Category: Aberg A]]
-[[Category: Aberg, A.]]
+[[Category: Andersson G]]
-[[Category: Andersson, G.]]
+[[Category: Garcin ED]]
-[[Category: Garcin, E D.]]
+[[Category: Getzoff ED]]
-[[Category: Getzoff, E D.]]
+[[Category: Panda K]]
-[[Category: Panda, K.]]
+[[Category: Rosenfeld RJ]]
-[[Category: Rosenfeld, R J.]]
+[[Category: Stuehr DJ]]
-[[Category: Stuehr, D J.]]
+[[Category: Tainer JA]]
-[[Category: Tainer, J A.]]
+[[Category: Wallace AV]]
-[[Category: Wallace, A V.]]
-[[Category: Inhibitor-induced conformational change]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 12:02:25 2009''