1lvf: Difference between revisions

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-[[Image:1lvf.gif|left|200px]]<br /><applet load="1lvf" size="350" color="white" frame="true" align="right" spinBox="true"
-caption="1lvf, resolution 2.10&Aring;" />
-'''syntaxin 6'''<br />
-==Overview==
+==syntaxin 6==
-Soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins are required for intracellular membrane fusion, and are differentially localized throughout the cell. SNAREs on vesicle and target membranes contain "SNARE motifs" which interact to form a four-helix bundle that contributes to the fusion of two membranes. SNARE motif sequences fall into four classes, homologous to the neuronal proteins syntaxin 1a, VAMP 2, and the N- and C-terminal SNARE motifs of SNAP-25 (S25N and S25C), and it is thought that one member from each class interacts to form a SNARE complex. Many SNAREs also feature N-terminal domains believed to function in regulating SNARE complex assembly or other aspects of vesicle transport. Syntaxin 6 is a SNARE found primarily in endosomal transport vesicles and whose SNARE motif shows significant homology to both syntaxin 1a and S25C. The crystal structure of the syntaxin 6 N-terminal domain reveals strong structural similarity with the N-terminal domains of syntaxin family members syntaxin 1a, Sso1p, and Vam3p, despite a very low level of sequence similarity. The syntaxin 6 SNARE motif can substitute for S25C in in vitro binding experiments, supporting the classification of syntaxin 6 as an S25C family member. Secondary structure prediction of SNARE proteins shows that the N-terminal domains of many syntaxin, S25N, and S25C family members are likely to be similar to one another, but are distinct from those of VAMP family members, indicating that syntaxin, S25N, and S25C SNAREs may have shared a common ancestor.
+<StructureSection load='1lvf' size='340' side='right'caption='[[1lvf]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1lvf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LVF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LVF FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lvf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lvf OCA], [https://pdbe.org/1lvf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lvf RCSB], [https://www.ebi.ac.uk/pdbsum/1lvf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lvf ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/STX6_RAT STX6_RAT] Involved in intracellular vesicle trafficking.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lv/1lvf_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lvf ConSurf].
+<div style="clear:both"></div>
-==About this Structure==
+==See Also==
-LVF is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LVF OCA].
+*[[Syntaxin 3D structures|Syntaxin 3D structures]]
+__TOC__
-==Reference==
+</StructureSection>
-Three-dimensional structure of the amino-terminal domain of syntaxin 6, a SNAP-25 C homolog., Misura KM, Bock JB, Gonzalez LC Jr, Scheller RH, Weis WI, Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9184-9. Epub 2002 Jun 24. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12082176 12082176]
+[[Category: Large Structures]]
 [[Category: Rattus norvegicus]]
-[[Category: Single protein]]
+[[Category: Bock JB]]
-[[Category: Bock, J B.]]
+[[Category: Gonzalez LC]]
-[[Category: Gonzalez, L C.]]
+[[Category: Misura KMS]]
-[[Category: Misura, K M.S.]]
+[[Category: Scheller RH]]
-[[Category: Scheller, R H.]]
+[[Category: Weis WI]]
-[[Category: Weis, W I.]]
-[[Category: snare]]
-[[Category: three-helix bundle]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:48:51 2008''