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[[Image:1lkf.png|left|200px]]


{{STRUCTURE_1lkf|  PDB=1lkf  |  SCENE=  }}
==LEUKOCIDIN F (HLGB) FROM STAPHYLOCOCCUS AUREUS==
 
<StructureSection load='1lkf' size='340' side='right'caption='[[1lkf]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
===LEUKOCIDIN F (HLGB) FROM STAPHYLOCOCCUS AUREUS===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1lkf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LKF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LKF FirstGlance]. <br>
{{ABSTRACT_PUBMED_10048924}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lkf OCA], [https://pdbe.org/1lkf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lkf RCSB], [https://www.ebi.ac.uk/pdbsum/1lkf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lkf ProSAT]</span></td></tr>
==About this Structure==
</table>
[[1lkf]] is a 1 chain structure of [[Pore forming toxin%2C α-hemolysin]] with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LKF OCA].  
== Function ==
[https://www.uniprot.org/uniprot/HLGB_STAAU HLGB_STAAU] Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lk/1lkf_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lkf ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Pore forming toxin%2C α-hemolysin|Pore forming toxin%2C α-hemolysin]]
*[[Pore forming toxin%2C α-hemolysin|Pore forming toxin%2C α-hemolysin]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:010048924</ref><references group="xtra"/>
[[Category: Large Structures]]
[[Category: Staphylococcus aureus]]
[[Category: Staphylococcus aureus]]
[[Category: Gouaux, J E.]]
[[Category: Gouaux JE]]
[[Category: Kamio, Y.]]
[[Category: Kamio Y]]
[[Category: Nariya, H.]]
[[Category: Nariya H]]
[[Category: Olson, R.]]
[[Category: Olson R]]
[[Category: Yokota, K.]]
[[Category: Yokota K]]
[[Category: Hemolysin]]
[[Category: Leukotoxin]]
[[Category: Pore-forming toxin]]
[[Category: Toxin]]

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