1lio: Difference between revisions

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[[Image:1lio.png|left|200px]]


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==STRUCTURE OF APO T. GONDII ADENOSINE KINASE==
The line below this paragraph, containing "STRUCTURE_1lio", creates the "Structure Box" on the page.
<StructureSection load='1lio' size='340' side='right'caption='[[1lio]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1lio]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1dh2 1dh2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LIO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LIO FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lio FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lio OCA], [https://pdbe.org/1lio PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lio RCSB], [https://www.ebi.ac.uk/pdbsum/1lio PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lio ProSAT]</span></td></tr>
{{STRUCTURE_1lio|  PDB=1lio |  SCENE= }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/ADK_TOXGO ADK_TOXGO] ATP-dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. It is a key purine metabolic enzyme in the opportunistic parasitic protozoan toxoplasma gondii as it cannot synthesize purines de novo.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/li/1lio_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lio ConSurf].
<div style="clear:both"></div>


===STRUCTURE OF APO T. GONDII ADENOSINE KINASE===
==See Also==
 
*[[Adenosine kinase 3D structures|Adenosine kinase 3D structures]]
 
__TOC__
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_10801355}}
 
==About this Structure==
1LIO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1dh2 1dh2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LIO OCA].
 
==Reference==
Crystal structures of Toxoplasma gondii adenosine kinase reveal a novel catalytic mechanism and prodrug binding., Schumacher MA, Scott DM, Mathews II, Ealick SE, Roos DS, Ullman B, Brennan RG, J Mol Biol. 2000 May 19;298(5):875-93. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10801355 10801355]
[[Category: Adenosine kinase]]
[[Category: Single protein]]
[[Category: Toxoplasma gondii]]
[[Category: Toxoplasma gondii]]
[[Category: Brennan, R G.]]
[[Category: Brennan RG]]
[[Category: Ealick, S E.]]
[[Category: Ealick SE]]
[[Category: Matthews, I I.]]
[[Category: Mathews II]]
[[Category: Schumacher, M A.]]
[[Category: Schumacher MA]]
[[Category: Scott, D M.]]
[[Category: Scott DM]]
[[Category: Alpha-beta structure]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul  2 20:59:11 2008''

Latest revision as of 10:33, 14 February 2024

STRUCTURE OF APO T. GONDII ADENOSINE KINASESTRUCTURE OF APO T. GONDII ADENOSINE KINASE

Structural highlights

1lio is a 1 chain structure with sequence from Toxoplasma gondii. This structure supersedes the now removed PDB entry 1dh2. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.5Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ADK_TOXGO ATP-dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. It is a key purine metabolic enzyme in the opportunistic parasitic protozoan toxoplasma gondii as it cannot synthesize purines de novo.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1lio, resolution 2.50Å

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