1lhs: Difference between revisions

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<StructureSection load='1lhs' size='340' side='right'caption='[[1lhs]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='1lhs' size='340' side='right'caption='[[1lhs]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1lhs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Carcr Carcr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LHS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LHS FirstGlance]. <br>
<table><tr><td colspan='2'>[[1lhs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Caretta_caretta Caretta caretta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LHS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LHS FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lhs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lhs OCA], [https://pdbe.org/1lhs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lhs RCSB], [https://www.ebi.ac.uk/pdbsum/1lhs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lhs ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lhs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lhs OCA], [https://pdbe.org/1lhs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lhs RCSB], [https://www.ebi.ac.uk/pdbsum/1lhs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lhs ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/MYG_CARCR MYG_CARCR]] Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.  
[https://www.uniprot.org/uniprot/MYG_CARCR MYG_CARCR] Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lhs ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lhs ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The X-ray crystal structures of the aquo-met and cyano-met derivatives of the loggerhead sea turtle (Caretta caretta) myoglobin have been determined at 2.0 A resolution (R = 0.182, and 0.178, respectively). The results here reported, representing the first reptile globin solved by X-ray crystallography, have been analyzed in parallel with data for related monomeric hemoproteins, and indicate a strong overall structural similarity between the loggerhead sea turtle and mammalian myoglobins, reflected by the 63% amino acid identity of their primary structures. The root-mean-square deviation between the entire polypeptide backbones of loggerhead sea turtle and sperm whale myoglobins, after structure superposition, is 0.83 A. Upon cyanide binding to the protein distal site, the iron-bound water molecule present in the aquo-met form is displaced by the incoming ligand. Cyanide is oriented towards the inner part of the heme distal site forming a Fe-C-N angle of 133 degrees.
Reptile heme protein structure: X-ray crystallographic study of the aquo-met and cyano-met derivatives of the loggerhead sea turtle (Caretta caretta) myoglobin at 2.0 A resolution.,Nardini M, Tarricone C, Rizzi M, Lania A, Desideri A, De Sanctis G, Coletta M, Petruzzelli R, Ascenzi P, Coda A, et al. J Mol Biol. 1995 Mar 31;247(3):459-65. PMID:7714901<ref>PMID:7714901</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1lhs" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Myoglobin 3D structures|Myoglobin 3D structures]]
*[[Myoglobin 3D structures|Myoglobin 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Carcr]]
[[Category: Caretta caretta]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Ascenzi, P]]
[[Category: Ascenzi P]]
[[Category: Bolognesi, M]]
[[Category: Bolognesi M]]
[[Category: Coda, A]]
[[Category: Coda A]]
[[Category: Coletta, M]]
[[Category: Coletta M]]
[[Category: Desideri, A]]
[[Category: De Sanctis G]]
[[Category: Lania, A]]
[[Category: Desideri A]]
[[Category: Nardini, M]]
[[Category: Lania A]]
[[Category: Petruzzelli, R]]
[[Category: Nardini M]]
[[Category: Sanctis, G De]]
[[Category: Petruzzelli R]]
[[Category: Tarricone, C]]
[[Category: Tarricone C]]
[[Category: Oxygen storage]]

Latest revision as of 10:33, 14 February 2024

LOGGERHEAD SEA TURTLE MYOGLOBIN (AQUO-MET)LOGGERHEAD SEA TURTLE MYOGLOBIN (AQUO-MET)

Structural highlights

1lhs is a 1 chain structure with sequence from Caretta caretta. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

MYG_CARCR Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1lhs, resolution 2.00Å

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
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