1lep: Difference between revisions

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OCA

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-[[Image:1lep.jpg|left|200px]]<br /><applet load="1lep" size="450" color="white" frame="true" align="right" spinBox="true"
-caption="1lep, resolution 3.5&Aring;" />
-'''THREE-DIMENSIONAL STRUCTURE OF THE IMMUNODOMINANT HEAT-SHOCK PROTEIN CHAPERONIN-10 OF MYCOBACTERIUM LEPRAE'''<br />
-==Overview==
+==THREE-DIMENSIONAL STRUCTURE OF THE IMMUNODOMINANT HEAT-SHOCK PROTEIN CHAPERONIN-10 OF MYCOBACTERIUM LEPRAE==
-Members of the chaperonin-10 (cpn10) protein family, also called heat, shock protein 10 and in Escherichia coli GroES, play an important role in, ensuring the proper folding of many proteins. The crystal structure of the, Mycobacterium leprae cpn10 (Ml-cpn10) oligomer has been elucidated at a, resolution of 3.5 angstroms. The architecture of the Ml-cpn10 heptamer, resembles a dome with an oculus in its roof. The inner surface of the dome, is hydrophilic and highly charged. A flexible region, known to interact, with cpn60, extends from the lower rim of the dome. With the structure of, a cpn10 heptamer now revealed and the structure of the E. coli GroEL, previously known, models of cpn10:cpn60 and GroEL:GroES complexes are, proposed.
+<StructureSection load='1lep' size='340' side='right'caption='[[1lep]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1lep]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_leprae Mycobacterium leprae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LEP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LEP FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lep FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lep OCA], [https://pdbe.org/1lep PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lep RCSB], [https://www.ebi.ac.uk/pdbsum/1lep PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lep ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CH10_MYCLE CH10_MYCLE] Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.[HAMAP-Rule:MF_00580]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/le/1lep_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lep ConSurf].
+<div style="clear:both"></div>
-==About this Structure==
+==See Also==
-LEP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_leprae Mycobacterium leprae]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1LEP OCA].
+*[[Chaperonin 3D structures|Chaperonin 3D structures]]
+__TOC__
-==Reference==
+</StructureSection>
-Structure of the heat shock protein chaperonin-10 of Mycobacterium leprae., Mande SC, Mehra V, Bloom BR, Hol WG, Science. 1996 Jan 12;271(5246):203-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8539620 8539620]
+[[Category: Large Structures]]
 [[Category: Mycobacterium leprae]]
-[[Category: Single protein]]
+[[Category: Hol WGJ]]
-[[Category: Hol, W.G.J.]]
+[[Category: Mande SC]]
-[[Category: Mande, S.C.]]
-[[Category: antigen]]
-[[Category: chaperone]]
-[[Category: heat shock]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 20:31:27 2007''