1l2h: Difference between revisions

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-[[Image:1l2h.png|left|200px]]
-{{STRUCTURE_1l2h|  PDB=1l2h  |  SCENE=  }}
+==Crystal structure of Interleukin 1-beta F42W/W120F mutant==
+<StructureSection load='1l2h' size='340' side='right'caption='[[1l2h]], [[Resolution|resolution]] 1.54&Aring;' scene=''>
-===Crystal structure of Interleukin 1-beta F42W/W120F mutant===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1l2h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L2H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L2H FirstGlance]. <br>
-{{ABSTRACT_PUBMED_12554939}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.54&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l2h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l2h OCA], [https://pdbe.org/1l2h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l2h RCSB], [https://www.ebi.ac.uk/pdbsum/1l2h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l2h ProSAT]</span></td></tr>
-==About this Structure==
+</table>
-[[1l2h]] is a 1 chain structure of [[Interleukin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L2H OCA].
+== Function ==
+[https://www.uniprot.org/uniprot/IL1B_HUMAN IL1B_HUMAN] Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.<ref>PMID:3920526</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l2/1l2h_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1l2h ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Interleukin|Interleukin]]
+*[[Interleukin 3D structures|Interleukin 3D structures]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:012554939</ref><references group="xtra"/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Heidary, D K.]]
+[[Category: Large Structures]]
-[[Category: Jennings, P A.]]
+[[Category: Heidary DK]]
-[[Category: Kelker, M S.]]
+[[Category: Jennings PA]]
-[[Category: Oseroff, V.]]
+[[Category: Kelker MS]]
-[[Category: Rudolph, M G.]]
+[[Category: Oseroff V]]
-[[Category: Schneider, T R.]]
+[[Category: Rudolph MG]]
-[[Category: Wilson, I A.]]
+[[Category: Schneider TR]]
-[[Category: Yeates, T O.]]
+[[Category: Wilson IA]]
-[[Category: Beta-trefoil]]
+[[Category: Yeates TO]]
-[[Category: F42w/w120f double mutant]]
-[[Category: Hemihedral twinning]]
-[[Category: Immune system]]
-[[Category: Interleukin-1 beta]]
-[[Category: Mad phasing]]
-[[Category: Protein folding]]