1l1f: Difference between revisions

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-{{Seed}}
-[[Image:1l1f.png|left|200px]]
-<!--
+==Structure of human glutamate dehydrogenase-apo form==
-The line below this paragraph, containing "STRUCTURE_1l1f", creates the "Structure Box" on the page.
+<StructureSection load='1l1f' size='340' side='right'caption='[[1l1f]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1l1f]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L1F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L1F FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l1f OCA], [https://pdbe.org/1l1f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l1f RCSB], [https://www.ebi.ac.uk/pdbsum/1l1f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l1f ProSAT]</span></td></tr>
-{{STRUCTURE_1l1f|  PDB=1l1f  |  SCENE=  }}
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/DHE3_HUMAN DHE3_HUMAN] Defects in GLUD1 are the cause of familial hyperinsulinemic hypoglycemia type 6 (HHF6) [MIM:[https://omim.org/entry/606762 606762]; also known as hyperinsulinism-hyperammonemia syndrome (HHS). Familial hyperinsulinemic hypoglycemia [MIM:[https://omim.org/entry/256450 256450], also referred to as congenital hyperinsulinism, nesidioblastosis, or persistent hyperinsulinemic hypoglycemia of infancy (PPHI), is the most common cause of persistent hypoglycemia in infancy and is due to defective negative feedback regulation of insulin secretion by low glucose levels. In HHF6 elevated oxidation rate of glutamate to alpha-ketoglutarate stimulates insulin secretion in the pancreatic beta cells, while they impair detoxification of ammonium in the liver.<ref>PMID:9571255</ref> <ref>PMID:10636977</ref> <ref>PMID:11214910</ref> <ref>PMID:11297618</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/DHE3_HUMAN DHE3_HUMAN] May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity).
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l1/1l1f_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1l1f ConSurf].
+<div style="clear:both"></div>
-===Structure of human glutamate dehydrogenase-apo form===
+==See Also==
+*[[Glutamate dehydrogenase 3D structures|Glutamate dehydrogenase 3D structures]]
+== References ==
-<!--
+<references/>
-The line below this paragraph, {{ABSTRACT_PUBMED_12054821}}, adds the Publication Abstract to the page
+__TOC__
-(as it appears on PubMed at http://www.pubmed.gov), where 12054821 is the PubMed ID number.
+</StructureSection>
--->
-{{ABSTRACT_PUBMED_12054821}}
-==About this Structure==
-L1F is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L1F OCA].
-==Reference==
-<ref group="xtra">PMID:12054821</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Fang, J.]]
+[[Category: Large Structures]]
-[[Category: Schmidt, T.]]
+[[Category: Fang J]]
-[[Category: Siuzdak, G.]]
+[[Category: Schmidt T]]
-[[Category: Smith, T J.]]
+[[Category: Siuzdak G]]
-[[Category: Stanley, C A.]]
+[[Category: Smith TJ]]
-[[Category: Wu, J.]]
+[[Category: Stanley CA]]
-[[Category: Allostery]]
+[[Category: Wu J]]
-[[Category: Negative cooperativity]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 06:07:42 2009''