1kxu: Difference between revisions

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[[Image:1kxu.png|left|200px]]


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==CYCLIN H, A POSITIVE REGULATORY SUBUNIT OF CDK ACTIVATING KINASE==
The line below this paragraph, containing "STRUCTURE_1kxu", creates the "Structure Box" on the page.
<StructureSection load='1kxu' size='340' side='right'caption='[[1kxu]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1kxu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KXU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KXU FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kxu OCA], [https://pdbe.org/1kxu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kxu RCSB], [https://www.ebi.ac.uk/pdbsum/1kxu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kxu ProSAT]</span></td></tr>
{{STRUCTURE_1kxu| PDB=1kxu |  SCENE= }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/CCNH_HUMAN CCNH_HUMAN] Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.<ref>PMID:7533895</ref> <ref>PMID:10024882</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kx/1kxu_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kxu ConSurf].
<div style="clear:both"></div>


===CYCLIN H, A POSITIVE REGULATORY SUBUNIT OF CDK ACTIVATING KINASE===
==See Also==
 
*[[Cyclin 3D structures|Cyclin 3D structures]]
 
== References ==
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{{ABSTRACT_PUBMED_8836101}}
 
==About this Structure==
1KXU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KXU OCA].
 
==Reference==
Three-dimensional structure of human cyclin H, a positive regulator of the CDK-activating kinase., Kim KK, Chamberlin HM, Morgan DO, Kim SH, Nat Struct Biol. 1996 Oct;3(10):849-55. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8836101 8836101]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Chamberin, H M.]]
[[Category: Chamberin HM]]
[[Category: Kim, K K.]]
[[Category: Kim KK]]
[[Category: Kim, S H.]]
[[Category: Kim S-H]]
[[Category: Morgan, D O.]]
[[Category: Morgan DO]]
[[Category: Alpha-helical structure]]
[[Category: Cell cycle]]
[[Category: Cell division]]
[[Category: Cyclin]]
[[Category: Nuclear protein]]
[[Category: Regulatory protein]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul  2 11:15:16 2008''

Latest revision as of 10:28, 14 February 2024

CYCLIN H, A POSITIVE REGULATORY SUBUNIT OF CDK ACTIVATING KINASECYCLIN H, A POSITIVE REGULATORY SUBUNIT OF CDK ACTIVATING KINASE

Structural highlights

1kxu is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.6Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CCNH_HUMAN Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.[1] [2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Shiekhattar R, Mermelstein F, Fisher RP, Drapkin R, Dynlacht B, Wessling HC, Morgan DO, Reinberg D. Cdk-activating kinase complex is a component of human transcription factor TFIIH. Nature. 1995 Mar 16;374(6519):283-7. PMID:7533895 doi:http://dx.doi.org/10.1038/374283a0
  2. ↑ Tirode F, Busso D, Coin F, Egly JM. Reconstitution of the transcription factor TFIIH: assignment of functions for the three enzymatic subunits, XPB, XPD, and cdk7. Mol Cell. 1999 Jan;3(1):87-95. PMID:10024882

1kxu, resolution 2.60Å

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