1kuv: Difference between revisions

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[[Image:1kuv.png|left|200px]]


{{STRUCTURE_1kuv|  PDB=1kuv  |  SCENE=  }}
==X-ray Crystallographic Studies of Serotonin N-acetyltransferase Catalysis and Inhibition==
 
<StructureSection load='1kuv' size='340' side='right'caption='[[1kuv]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
===X-ray Crystallographic Studies of Serotonin N-acetyltransferase Catalysis and Inhibition===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1kuv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ovis_aries Ovis aries]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KUV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KUV FirstGlance]. <br>
{{ABSTRACT_PUBMED_11902838}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA5:COA-S-ACETYL+5-BROMOTRYPTAMINE'>CA5</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kuv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kuv OCA], [https://pdbe.org/1kuv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kuv RCSB], [https://www.ebi.ac.uk/pdbsum/1kuv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kuv ProSAT]</span></td></tr>
[[1kuv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ovis_aries Ovis aries]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KUV OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/SNAT_SHEEP SNAT_SHEEP] Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin.<ref>PMID:15644438</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ku/1kuv_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kuv ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Serotonin N-acetyltransferase|Serotonin N-acetyltransferase]]
*[[Serotonin N-acetyltransferase|Serotonin N-acetyltransferase]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:011902838</ref><references group="xtra"/>
__TOC__
[[Category: Aralkylamine N-acetyltransferase]]
</StructureSection>
[[Category: Large Structures]]
[[Category: Ovis aries]]
[[Category: Ovis aries]]
[[Category: Angelis, J De.]]
[[Category: Burley SK]]
[[Category: Burley, S K.]]
[[Category: Cole PA]]
[[Category: Cole, P A.]]
[[Category: De Angelis J]]
[[Category: Khalil, E M.]]
[[Category: Khalil EM]]
[[Category: Wolf, E.]]
[[Category: Wolf E]]
[[Category: Alternate conformation]]
[[Category: Bisubstrate analog]]
[[Category: Enzyme-inhibitor complex]]
[[Category: Transferase]]

Latest revision as of 10:27, 14 February 2024

X-ray Crystallographic Studies of Serotonin N-acetyltransferase Catalysis and InhibitionX-ray Crystallographic Studies of Serotonin N-acetyltransferase Catalysis and Inhibition

Structural highlights

1kuv is a 1 chain structure with sequence from Ovis aries. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SNAT_SHEEP Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Ganguly S, Weller JL, Ho A, Chemineau P, Malpaux B, Klein DC. Melatonin synthesis: 14-3-3-dependent activation and inhibition of arylalkylamine N-acetyltransferase mediated by phosphoserine-205. Proc Natl Acad Sci U S A. 2005 Jan 25;102(4):1222-7. Epub 2005 Jan 11. PMID:15644438 doi:0406871102

1kuv, resolution 2.00Å

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