1kuv: Difference between revisions

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-[[Image:1kuv.png|left|200px]]
-{{STRUCTURE_1kuv|  PDB=1kuv  |  SCENE=  }}
+==X-ray Crystallographic Studies of Serotonin N-acetyltransferase Catalysis and Inhibition==
+<StructureSection load='1kuv' size='340' side='right'caption='[[1kuv]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-===X-ray Crystallographic Studies of Serotonin N-acetyltransferase Catalysis and Inhibition===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1kuv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ovis_aries Ovis aries]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KUV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KUV FirstGlance]. <br>
-{{ABSTRACT_PUBMED_11902838}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA5:COA-S-ACETYL+5-BROMOTRYPTAMINE'>CA5</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kuv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kuv OCA], [https://pdbe.org/1kuv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kuv RCSB], [https://www.ebi.ac.uk/pdbsum/1kuv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kuv ProSAT]</span></td></tr>
-[[1kuv]] is a 1 chain structure of [[Serotonin N-acetyltransferase]] with sequence from [http://en.wikipedia.org/wiki/Ovis_aries Ovis aries]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KUV OCA].
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/SNAT_SHEEP SNAT_SHEEP] Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin.<ref>PMID:15644438</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ku/1kuv_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kuv ConSurf].
+<div style="clear:both"></div>
 ==See Also==
 *[[Serotonin N-acetyltransferase|Serotonin N-acetyltransferase]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:011902838</ref><references group="xtra"/>
+__TOC__
-[[Category: Aralkylamine N-acetyltransferase]]
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Ovis aries]]
-[[Category: Angelis, J De.]]
+[[Category: Burley SK]]
-[[Category: Burley, S K.]]
+[[Category: Cole PA]]
-[[Category: Cole, P A.]]
+[[Category: De Angelis J]]
-[[Category: Khalil, E M.]]
+[[Category: Khalil EM]]
-[[Category: Wolf, E.]]
+[[Category: Wolf E]]
-[[Category: Alternate conformation]]
-[[Category: Bisubstrate analog]]
-[[Category: Enzyme-inhibitor complex]]
-[[Category: Transferase]]